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This product is freeze dried. All water molecules have been removed.
This antibody is shipped with its antigen FREE of charge!
This product is "conjugated" to a fluorescent dye.
This antibody has undergone quality control and has been approved by our professional team.
This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
___ Cells + Rabbit IgG isotype control-FITC
___ Cells + Anti-Plexin-A1 (extracellular)-FITC antibody (APR-081-F), (2.5 µg antibody/0.5x106 cells).
___ Cells + rabbit IgG isotype control-FITC
___ Cells + Anti-Plexin-A1 (extracellular)-FITC antibody (APR-081-F), (5 µg antibody/0.5x106 cells).
The plexin family are transmembrane receptors, comprises four subfamilies- plexin-A, B, C, and D. In human, three members of the plexin-A subfamily have been isolated- plexin-A1, A2, and A3. Plexin A1 is encoded by the PLXNA1 gene.
These receptors are characterized by the presence of a conserved intracellular domain of about 600 amino acids known as the sex and plexins domain. This domain is strikingly conserved across the plexin family and consists of two blocks of high sequence conservation separated by a variable linker. The ectodomains of the plexin-A subfamily possess three repeats of the cysteine cluster/Met-Related Sequences.
Plexins act as signal-transducing components containing transmembrane domain of six Gly residues constituting a GxGGGGG motif.
Plexins act as functional receptors for members of the semaphorin family. Together they transmit repulsive axon guidance signals for semaphorins inside the axonal growth cone. The plexins act together with their co-receptors, neuropilins. Plexin-A1, in combination with neuropilins exhibits various functions in axon guidance, organogenesis, angiogenesis, tumorigenesis, and immune regulation1-3.
Plexin-A1 also plays an important role in the developmental stages of chick heart by working as a receptor for one of the transmembrane semaphorins. In addition Plexin-A1 expressed in dendritic cells is involved in T-dendritic cell interactions in the immune system4.
Species reactivity key:
Anti-Plexin-A1 (extracellular) (#APR-081) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the protein in living cells. It has been designed to recognize Plexin-A1 from mouse, rat, and human samples.
Alomone Labs is pleased to offer a new version of this antibody that is directly conjugated to fluorescein isothiocyanate (FITC). Anti-Plexin-A1 (extracellular)-FITC antibody (#APR-081-F) can be used in immunofluorescent applications such as direct live cell flow cytometry.
- Anti-Plexin-A1 (extracellular) antibody (#APR-081), (for western blot analysis).