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Peptide (C)RPPVQGRSTSQQGE, corresponding to amino acid residues 510-523 of rat Synapsin III (Accession O70441). Extracellular, C-terminus.
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates:1,2. Anti-Synapsin III (SYN3) Antibody (#ANR-017), (1:400).
3,4. Anti-Synapsin III (SYN3) Antibody, preincubated with the control peptide antigen.Western blot analysis human SH-SY5Y neuroblastoma cell line lysate:1. Anti-Synapsin III (SYN3) Antibody (#ANR-017), (1:200).
2. Anti-Synapsin III (SYN3) Antibody, preincubated with the control peptide antigen.
Expression of Synapsin 3 in mouse and rat hippocampusImmunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-Synapsin III (SYN3) Antibody (#ANR-017), (1:200), followed by goat anti-rabbit-AlexaFluor-488. A. SYN3 staining (green) in mouse hippocampal CA3 region is detected in the mossy fiber terminal (MFT) region. B. In rat hippocampal dentate gyrus (DG) region, SYN3 immunoreactivity (green) is observed in hilus of the dentate gyrus. Cell nuclei are stained with DAPI (blue).
Synapsin 3 (Syn3) belongs to the synapsin family of neuronal phosphoproteins, vesicle-associated proteins that includes two additional members: Synapsin I and Synapsin II. Alternative splicing of the genes results in at least ten variants with various levels of homology.
Synapsins are involved in synaptogenesis, synaptic transmission and synaptic plasticity and are required for the formation and maintenance of the reserve and recycling pools of synaptic vesicles through association with the actin cytoskeleton. Several protein kinases, including PKA, calcium-calmodulin regulated protein kinases and the mitogen-activated protein kinase (MAPK) use synapsins as their substrates1-4.
Syn3 plays an important role in several disorders, including bipolar disorder, schizophrenia and epilepsy1.
Species reactivity key:
Anti-Synapsin III (SYN3) Antibody (#ANR-017) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Synapsin III from human, rat, and mouse samples.