Overview
- Peptide CKDGQVRRVKGFHS, corresponding to amino acid residues 508 - 521 of mouse TAS1R3 (Accession Q925D8). Extracellular, N-terminus.
Taste Receptor Type 1 Member 3 (TAS1R3) (extracellular) Blocking Peptide (#BLP-TR016)
Taste receptor type 1 member 3 (TAS1R3), commonly known as T1R3, is a key component in the detection of sweet and umami tastes. TAS1R3 is part of the Class C G-protein-coupled receptor (GPCR) family and functions as a heterodimer with TAS1R1 or TAS1R2 to mediate umami and sweet taste perception, respectively. Structurally, members of this family share a large extracellular ligand-binding domain, seven transmembrane domains, and intracellular signaling regions1,3.
TAS1R3 is localized primarily on the cell membrane of taste receptor cells within taste buds in the tongue’s fungiform, foliate, and circumvallate papillae3,5. TAS1R3 expression extends to the gastrointestinal tract and specific enteroendocrine cells, linking its activation to nutrient sensing and gut hormone secretion2,4. Emerging evidence suggests that TAS1R3 is expressed in the hypothalamus, particularly in the paraventricular and arcuate nuclei, where it could play a role in integrating peripheral nutrient signals with neuroendocrine and behavioral responses6.
Upon binding of sugars, amino acids, or fatty acids, TAS1R3 activates downstream signaling via the Gα-gustducin and phospholipase Cβ2 pathways, leading to calcium mobilization and neurotransmitter release3,5. TAS1R3-mediated signaling plays a significant role in nutrient detection, appetite regulation, and gut-brain axis communication. Dysfunction or altered TAS1R3 expression is implicated in metabolic disorders such as obesity, diabetes, and intestinal inflammation4.