Certificate of Analysis

AZD-1332

Name: AZD-1332
Brand: Alomone Labs
SKU: A-495

AZ-23 racemate, AZ-23 compound, 5-Chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine

A Potent and Selective Inhibitor of TrkA, TrkB, TrkC Receptors

Cat #: A-495

Alternative Name AZ-23 racemate, AZ-23 compound, 5-Chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine

Lyophilized Powder yes

Bioassay Tested

Source Synthetic

MW: 391.8

Purity: >95%

Effective concentration 1-100 nM.

Structure

Chemical name 5-chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine.

Molecular formula C₁₇H₁₉ClFN₇O.

PubChem CID 49831044

Activity AZD-1332 is a potent, selective, and orally bioavailable inhibitor of tyrosine kinase receptors (IC₅₀ values of <10nM for TrkA and TrkB)¹.

References-Activity

Thress, K. et al. (2009) Mol. Cancer. Ther. 8, 1818.

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Our bioassay

Alomone Labs AZD-1332 inhibits NGF-mediated survival of serum-deprived PC12 cells.
Dose-response curve of AZD-1332 (#A-495) inhibition of Native mouse NGF 2.5S protein (>95%) (#N-100) mediated survival of serum-deprived PC12 cells. Cell viability was determined by the XTT method and normalized to control. IC₅₀ was calculated at 1.9 nM.

Scientific background

AZD-1332 is a potent and selective inhibitor of the Tropomyosin-related kinase (TrkA, TrkB, and TrkC) receptors. The compound is at least 30-fold more specific towards Trk in cell-based assays over a wide range of other kinases tested. AZD-1332 inhibits Trk kinase activity in cells at low nanomolar concentrations, the compound demonstrates IC₅₀ values of <10 nM for TrkA and TrkB¹_.

TrkA, TrkB, and TrkC receptors are involved in neuronal cell growth, development, and survival. Trk receptors are also potent oncogenes involved in malignant transformation, metastasis, and survival signaling in human tumors^1,2.

Target TrkA, TrkB, TrkC receptors

Lyophilized Powder

Last update: 02/01/2022

For research purposes only, not for human use

Specifications

Citations

Applications

Scientific Background

Shipping and Ordering information

Order Summary