Bradykinin

Kallidin I
A Ligand of the B2 Bradykinin G-Protein Coupled Receptor
    Cat #: GPB-200
    Alternative Name Kallidin I
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Synthetic peptide
    MW: 1060.23 Da.
    Purity: >98% (HPLC)
    Effective concentration 30-300 nM.
    Sequence RPPGFSPFR.
      • Bradykinin
    Molecular formula C50H73N15O11.
    CAS No.: 6846-03-3.
    Activity Bradykinin is an endothelial dependent vasodilator and hypotensive agent1.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
      • Bradykinin
        Alomone Labs Bradykinin induces store-operated Ca2+ release in RAEC cells.
        Cells were loaded with Fluo-3 AM. Intracellular Ca2+ fluctuations were measured in the presence of EGTA and increasing Bradykinin (#GPB-200) concentrations. The fluorescence is plotted against Bradykinin concentrations (ED50 = 93 ng/ml).
    References - Scientific background
      • Bradykinin is a potent effector peptide that binds the bradykinin receptors B2. Bradykinin reduces blood pressure and increases vascular permeability by inducing smooth muscle relaxation and blood vessel dilation1.

        Bradykinin is one the most potent known factors inducing pain substances that acts on afferent sensory neurons Bradykinin stimulates the synthesis of prostaglandins2 and is a major contributor to the innate inflammatory response3. Injection of Bradykinin into the skin produces all the inflammation basic signs4. Bradykinin has been implicated also in various shock syndromes5. Application of Bradykinin to the central nervous system appears to initiate events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function6.

    Target B2 bradykinin receptor
    Net Peptide Content: 100%
    Last update: 06/11/2019

    Bradykinin (#GPB-200) is a highly pure, synthetic, and biologically active protein.

    For research purposes only, not for human use