Candesartan cilexetil

Atacand, Parapres, Kenzen
An Antagonist of Angiotensin II Receptor Type-1 and Angiotensin II Receptor Type-2
    Cat #: C-265
    Alternative Name Atacand, Parapres, Kenzen
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 610.66
    Purity: ≥97%
    Effective concentration 1 nM-100 nM.
      • Candesartan cilexetil
    Chemical name 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate.
    Molecular formula C33H34N6O6.
    CAS No.: 145040-37-5.
    PubChem CID 2540
    Activity Candesartan is an Angiotensin II type 1 and 2 receptor antagonist1,2.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • Candesartan cilexetil
        Alomone Labs Candesartan cilexetil inhibits the activation of Angiotensin AT1R expressed in CHO-K1-mt Aequorin-Gα16 cells.
        Dose-response curve for the inhibition of AT1R expressed in CHO-K1-mt aequorin-Gα16 cells. Ca2+ response, as detected by elevation in aequorin derived fluorescence following 0.04 nM Angiotensin II application, was inhibited by increasing concentrations of Candesartan cilexetil (#C-265). 10 nM Candesartan cilexetil fully inhibited the activation by Angiotensin II.
    References - Scientific background
      • Angiotensin II is responsible for vasoconstriction in the renin-angiotensin system. In addition to its direct effect on blood vessels, it stimulates the synthesis and release of aldosterone and also promotes renal tubular reabsorption of sodium, resulting in water retention1.

        Candesartan (Atacand, Parapres, Kenzen) is a synthetic antagonist of the Angiotensin II type 1 and 2 receptors. It has an effective concentration of 1-100 nM and an IC50 of 15 μg/kg. Candesartan is used for the treatment of essential hypertension and congestive heart failure with reduced ejection fraction under 40%. Moreover, Candesartan was found to be effective combined with hydrochlorodiazide for the treatment of severe hypertension. It is administered orally as a pro-drug which is activated by ester hydrolysis during absorption from the gut and has a low bioavailability of 15%. Candesartan has a higher affinity for the AT1 receptor than other drugs of its type such as irbesartan, valsartan and losartan, and also dissociates slower from the receptor enabling a longer half-life period of 9 hours. It is mainly secreted unchanged in the stool but undergoes some metabolism by CYP 2C92,3.

    Target Angiotensin II receptors
    Last update: 24/01/2020

    Candesartan cilexetil (#C-265) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use