Overview
Cat #:
C-170
Lyophilized Powder yes
Origin Mylabris phalerata (Chinese blister beetle).
Source Natural
MW: 196.2
Purity: >98%
Effective concentration 100 nM - 1 µM.
Structure
Chemical name (3aa,4b,7b,7aa)-Hexahydro-3a,7a-dimethyl-4,7- epoxyisobe nzofuran-1,3-dione.
Molecular formula C10H12O4.
CAS No.: 56-25-7
Activity Cantharidin is a potent inhibitor of PP1 and PP2A (IC50 = 1.7 and 0.16 µm respectively)1.
References-Activity
- Honkanen, R.E. (1993) FEBS Lett. 330, 283.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or six months at -20°C.
References - Scientific background
- Pearce, R.M. (1909) J. Exp. Med. 17, 532.
- Knapp, J. et al. (1999) J. Pharmacol. Exp. Ther. 289, 1480.
- Li, Y.M. and Casida, J.E. (1992) Proc. Natl. Acad. Sci. U.S.A. 15, 11867.
Scientific background
Cantharidin is a natural poisonous terpenoid derived from five-carbon isoprene units. Cantharidin is produced and secreted by many species of the blister beetle as an egg protective compound against predators. Cantharidin was isolated in 1810 and was discovered as a renal poison1.
Cantharidin is a cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 12 and 2A3 by competitively docking in the ligand binding site at the beta catalytic subunit of the enzyme3.
Lyophilized Powder
Cantharidin (#C-170) is a highly pure, natural, and biologically active compound.
For research purposes only, not for human use
Last Update: 13/10/2022
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