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A TRPA1 and TRPV1 Channel Activator

Cat #: C-255
  • Bioassay Tested
  • Origin Capsicum annuum L.
    Source Natural
    MW: 306.4
    Purity: >94% (HPLC)
    Form Oily material.
    Effective concentration 1-100 µM.
    Chemical name (4-hydroxy-3-methoxyphenyl)methyl (E)-8-methylnon-6-enoate.
    Molecular formula C18H26O4.
    CAS No.: 205687-01-0
    PubChem CID 9839519
    Activity Capsiate activates TRPV1 and TRPA1 channels with EC50 = 3 µM1.
    1. Shintaku, K. et al. (2011) Br. J. Pharmacol. 165, 1476.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Capsiate activates TRPA1 channels expressed in HEK-293 cells. 
      Alomone Labs Capsiate activates TRPA1 channels expressed in HEK-293 cells. 
      Dose-response curve for the activation of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+ measurements. Calcium signal was apparent with 50 and 100 µM Capsiate (#C-255).
    References - Scientific background
    1. Niemeyer, B.A. (2005) Naunyn-Schmiedebergs Arch. Pharmacol. 371, 285.
    2. Cvetkov, T.L. et al. (2011) J. Biol. Chem. 286, 38168.
    3. Shintaku, K. et al. (2011) Br. J. Pharmacol. 165, 1476.
    4. Masuda, Y. et al. (1985) J. Appl. Physiol. 95, 2408.
    5. Ludy, M. et al. (2011) Chem. Senses 37, 103.
    Scientific background

    Transient receptor potential vanilloid channels (TRPV) are members of the TRP channel superfamily. They are involved in many sensory processes such as pain, temperature and hearing1. Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel, which is expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and neuropathic pain signals. Numerous non-reactive compounds and electrophilic compounds, such as endogenous inflammatory mediators and exogenous pungent chemicals, can activate TRPA12.

    Capsiate is a natural agonist of TRPA1 and TRPV1 channels with an effective concentration of 1-100 μM and an EC50 of 3 μM when binding to TRPA1. Capsiate is produced by a non-pungent cultivar of red pepper called Capsicum annuum L and is hypothesized to enhance energy metabolism by activating the sympathetic system and suppressing inflammation3.

    Capsiate has also been found to suppress body fat accumulation in mice through the upregulation of uncoupling proteins. Uncoupling proteins play an important role in body weight maintenance, thermoregulation and energy expenditure4. The magnitude of the long-term weight loss effectiveness of capsaicin in humans has not been clearly demonstrated and further research is required in its relation to combating obesity5.

    Target TRPA1, TRPV1 channels
    Last update: 13/10/2022

    Capsiate (#C-255) is a highly pure, natural, and biologically active compound.

    For research purposes only, not for human use
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