CaV1.2a (CACNA1C) Channel Antibody and Membrane Fractions Kit

Kit Contains Anti-CaV1.2a (CACNA1C) Antibody and all Controls Necessary for Robust Western Blot Analysis
  • Lyophilized Powder
  • Antigen Incl.
Cat #: LK-104B
Sizes: 4 Vials
Last update: 14/07/2019

CaV1.2 (CACNA1C) Channel Overexpressed Membrane Fractions (#LX-104) are Xenopus oocyte membrane fractions overexpressing the CaV1.2 channel. CaV1.2 (CACNA1C) Channel Overexpressed Membrane Fractions are your positive control for validating Alomone Labs Anti-CaV1.2 (CACNA1C) Antibody (#ACC-003), Guinea pig Anti-CaV1.2 (CACNA1C) Antibody (#AGP-001) and Anti-CaV1.2a (CACNA1C) Antibody (#ACC-013).

Overexpressed Membrane Fractions are:
✓ Lyophilized powder
✓ Economical
✓ Shipped at room temperature (no need for dry ice and extra shipping costs)
✓ User-friendly & time-saving. Just add water, sample buffer and load your gel

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Anti-CaV1.2a (CACNA1C) Antibody
ACC-013 1 x 0.2 ml
CaV1.2 (CACNA1C) Channel Overexpressed Membrane Fractions
LX-104 2 x 0.1 ml
Note

Kit includes:
1 x 40 µg Anti-CaV1.2a (CACNA1C) Antibody control antigen
1 x 0.1 ml lyophilized non-injected Xenopus oocyte membrane lysate

Scientific Background
    • All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal, cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors.

      While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in the heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channel blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#SPC-650), Calciseptine (#C-500) and FS-2 (#F-700).

      There are two splice variants to the CaV1.2 channel designated CaV1.2a and CaV1.2b. The expression of the CaV1.2b variant is restricted to smooth muscle while CaV1.2a is specifically expressed in cardiac muscle.

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