- Lyophilized Powder Lyophilized Powder
This product is freeze dried. All water molecules have been removed.
- Antigen Incl. Control Antigen Included
This antibody is shipped with its antigen FREE of charge!
CaV1.2 (CACNA1C) Channel Overexpressed Membrane Fractions (#LX-104) are Xenopus oocyte membrane fractions overexpressing the CaV1.2 channel. CaV1.2 (CACNA1C) Channel Overexpressed Membrane Fractions are your positive control for validating Alomone Labs Anti-CaV1.2 (CACNA1C) Antibody (#ACC-003), Guinea pig Anti-CaV1.2 (CACNA1C) Antibody (#AGP-001) and Anti-CaV1.2a (CACNA1C) Antibody (#ACC-013).
Overexpressed Membrane Fractions are:
✓ Lyophilized powder
✓ Shipped at room temperature (no need for dry ice and extra shipping costs)
✓ User-friendly & time-saving. Just add water, sample buffer and load your gel
|Product Name||Cat #||Size|
Anti-CaV1.2a (CACNA1C) Antibody
|ACC-013||1 x 0.2 ml|
CaV1.2 (CACNA1C) Channel Overexpressing Membrane Fraction
|LX-104||1 x 0.2 ml|
1 x 40 µg Anti-CaV1.2a (CACNA1C) Antibody control antigen
1 x 0.1 ml lyophilized non-injected Xenopus oocyte membrane lysate
All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal, cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors.
While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in the heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channel blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#SPC-650), Calciseptine (#C-500) and FS-2 (#F-700).
There are two splice variants to the CaV1.2 channel designated CaV1.2a and CaV1.2b. The expression of the CaV1.2b variant is restricted to smooth muscle while CaV1.2a is specifically expressed in cardiac muscle.
Explorer kits & Research packs
- CaV1.2 (CACNA1C) Channel Overexpressing Membrane Fraction (#LX-104)
- CaV1.2 (CACNA1C) Channel Antibody and Membrane Fractions Kit (#LK-104A)
- CaV1.2 (CACNA1C) Channel Antibody and Membrane Fractions Kit (#LK-104C)
- L-Type CaV Channel Antibody Explorer Kit (#AK-215)
- L-Type CaV Channel Blocker Explorer Kit (#EK-103)