Cl-HIBO (chloro-homoibotenic acid) acts as a full agonist at AMPA receptors (AMPARs). Cl-HIBO is the most selective agonist reported to-date for GluR1/2. Thus, the compound is considered to be a valuable tool for studying the biological behavior and distribution of AMPARs¹.

The ionotropic glutamate AMPA receptors are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. The majority of this transmission in the mammalian central nervous system is mediated by the release of glutamate from the presynaptic terminal and its binding to glutamate receptors on the postsynaptic membrane².