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CX 546

An Agonist of AMPA Receptors

Cat #: C-210
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 247.3
    Purity: >99%
    Form Lyophilized powder.
    Effective concentration 10-630 µM.
    Chemical name (2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone.
    Molecular formula C14H17NO3.
    CAS No.: 215923-54-9
    Activity CX 546 is a selective AMPA receptor agonist1.
    1. Nagarajan, N. et al. (2001) Neuropharmacology 41, 650.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 126 mM in DMSO; 100 mM in ethanol. Centrifuge all product preparations before use (10000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs CX 546 potentiates GluA1 channels expressed in Xenopus oocytes.
      Alomone Labs CX 546 potentiates GluA1 channels expressed in Xenopus oocytes.
      Time course of current reversible potentiation by 12.6, 126 and 630 μM CX 546 (#C-210) of glutamate-elicited currents (100 μM, holding potential -80 mV).
    References - Scientific background
    1. Arai, A. and Lynch, G. (1998) Brain Res799, 235.
    2. Arai, A.C. and Kessler, M. (2007) Curr. Drug Targets 8, 583.
    3. Nagarajan, N. et al. (2001) Neuropharmacology 41, 650.
    Scientific background

    The AMPAkine families of drugs are positive allosteric modulators of AMPA receptors in the mammalian brain. These compounds facilitate learning and memory in both humans and animals. Positive modulation of AMPA receptors by AMPAkines can improve channel function by increasing receptor sensitivity to endogenous ligands and specific agonists1.

    The AMPAkine 1-(quinoxalin-6-ylcarbonyl)-piperidine (CX546) is a brain-penetrating compound, which facilitates AMPA receptor-mediated transmission. CX546 has an EC50 in a hippocampal slice preparation of 150 μM as measured by patch clamp in cultured hippocampal neurons. The action of CX546 on AMPA receptor transmission results in memory enhancement, which has been demonstrated in rodents, primates, and humans2.

    Recent findings now indicate that CX546-mediated AMPA receptor enhancement strengthens neuronal survival signaling, leading to concomitant reduction in hippocampal damage3.

    CX546 was researched as a treatment for Alzheimer's disease under the brand name Ampalex.

    Target AMPA receptors
    Last update: 06/11/2022

    CX 546 (#C-210) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information