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Cytochalasin E

An Anticancer Compound and a Protein Synthesis and Transport Inhibitor
Cat #: C-550
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Aspergillus clavatus.
    Source Natural
    MW: 495.6
    Purity: >99%
    Effective concentration 0.1-10 µM.
    Structure
    Chemical name 21,23-Dioxa[13]cytochalasa-13,19-diene-1,17,22- trione,6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-.
    Molecular formula C28H33NO7.
    CAS No.: 36011-19-5.
    Activity Cytochalasin E is a fungal toxin which inhibits actin polymerization and blocks the formation of microtubules by inhibiting cell division and cell migration1-4.
    References-Activity
    1. Smith, G.F. et al. (1967) Nature 216, 1134.
    2. Tellam, R. and Frieden, C. (1982) Biochemistry 21, 3207.
    3. Yahara, I. et al. (1982) J. Cell. Biol92, 69.
    4. Matsuyama, T. et al. (1991) J. Immunol146, 3736.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Water, DMSO, ethanol, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or six months at -20°C.
    Protect from light.
    Our bioassay
    • Alomone Labs Cytochalasin E inhibits actin polymerization in C6 glioma cells.
      Alomone Labs Cytochalasin E inhibits actin polymerization in C6 glioma cells.
      Cells were incubated in the absence (A) or presence (B) of 10 µM Cytochalasin E (#C-550) for 1 h at 37°C. The figure shows dual staining using Rhodamine-conjugated-Palloidine for actin filament staining (red) and DAPI for nucleus staining (blue).
    References - Scientific background
    1. Smith, G.F. et al. (1967) Nature 216, 1134.
    2. Tellam, R. and Frieden, C. (1982) Biochemistry 21, 3207.
    3. Yahara, I. et al. (1982) J. Cell Biol92, 69.
    4. Matsuyama, T. et al. (1991)  J. Immunol146, 3736.
    5. McDonald, T.P. et al. (1995) J. Biol. Chem270, 30359.
    6. Baeker, T.R. et al. (1987) J. Immunol138, 2691.
    Scientific background

    Cytochalasins are a group of fungal toxin metabolites which bind to actin and alter its polymerization. Cytochalasins bind to the barbed end of the actin filament and prevent both the association and dissociation of actin subunits by inhibiting cell microtubule formation, cell division and cell migration.1-4

    Cytochalasin E induced a rapid and sustained elevation of intracellular free Ca2+ in B lymphocytes by increasing the extracellular Ca2+ influx.5,6

    Last update: 16/08/2020

    Cytochalasin E (#C-550) is a highly pure, natural, and biologically active compound.

    For research purposes only, not for human use
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