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- Alomone Labs Cytochalasin E inhibits actin polymerization in C6 glioma cells.Cells were incubated in the absence (A) or presence (B) of 10 µM Cytochalasin E (#C-550) for 1 h at 37°C. The figure shows dual staining using Rhodamine-conjugated-Palloidine for actin filament staining (red) and DAPI for nucleus staining (blue).
Cytochalasins are a group of fungal toxin metabolites which bind to actin and alter its polymerization. Cytochalasins bind to the barbed end of the actin filament and prevent both the association and dissociation of actin subunits by inhibiting cell microtubule formation, cell division and cell migration.1-4
Cytochalasin E induced a rapid and sustained elevation of intracellular free Ca2+ in B lymphocytes by increasing the extracellular Ca2+ influx.5,6