Eliprodil

SL 82-0715
An Antagonist of NMDA Receptors and N- and P-Type CaV Channels
    Cat #: E-155
    Alternative Name SL 82-0715
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 347.9
    Purity: >99%
    Effective concentration 0.1-10 µM.
      • Eliprodil
    Chemical name 1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanol.
    Molecular formula C20H23ClFNO.
    CAS No.: 119431-25-3.
    PubChem CID 60703
    Activity Eliprodil is a non-competitive NR2B-selective NMDA glutamate receptor antagonist 1, N and P-type voltage-dependent Ca2+ channels blocker 2.
      • Avenet, P. et al. (1997) Neurosci. Lett. 223, 133.
      • BathC.P. et al. (1996). Eur. J. Pharmacol299, 103.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility >25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • Eliprodil
        Alomone Labs Eliprodil inhibits specific binding of Ifenprodil to rat brain cortex NMDA receptors at polyamine sites.
        Percent inhibition of specific binding of 2 nM [3H] Ifenprodil to membranes from rat brain cerebral cortex, plotted against concentrations of Eliprodil (#E-155). Full inhibition is achieved at 3 µM.
    References - Scientific background
    • 1. BathC.P. et al. (1996). Eur. J. Pharmacol299, 103.
    • 2. Black, S.A. et al. (2014) Front. Cell. Dev. Biol. 2, 45.
    • 3. Layer, R.T. et al. (1995) Pharmacol. Biochem. Behav. 52, 621.
      • Eliprodil, also known as SL 82-0715, is a non-competitive NMDA (N-methyl-D-aspartate) receptor antagonist with neuroprotective properties. Eliprodil blocks the receptor through interaction with a modulatory polyamine site. The drug has also been shown to inhibit neuronal N- and P-type Ca2+ channel currents1.

        NMDARs play an important role in a variety of cellular processes and brain functions including synaptic plasticity, addiction and stroke. They also mediate physiological functions such as learning and memory formation. They play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer’s disease2.

        Studies show that eliprodil has the ability to protect against ischaemia-induced neurodegeneration when the drug is administered post-occlusion and demonstrates antidepressant-like actions in preclinical tests predictive of clinical efficacy1,3.

    Target NMDA receptors, N-, P-type CaV channels

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    Last update: 24/09/2019

    Eliprodil (#E-155) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use