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Endothelin Receptor Basic Research Pack

All You Need for Endothelin Receptors Research
  • Lyophilized Powder
  • Antigen Incl.
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: ESB-940
Sizes: 12 Vials
Last update: 04/09/2018

Endothelin Receptor Basic Research Pack (#ESB-940) contains all you need for Endothelin Receptor research: Antibodies for each receptor and selective pharmacological tools, all in one budget friendly package!

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Anti-Endothelin Receptor A Antibody
 		AER-001 1 x 0.2 ml
Anti-Endothelin Receptor B Antibody
 		AER-002 1 x 0.2 ml
A-192621
 		A-360 1 x 10 mg
ACT-132577
 		A-350 1 x 10 mg
Bosentan hydrate
 		B-170 1 x 250 mg
BQ-123 sodium salt
 		B-185 1 x 10 mg
BQ-3020
 		SPE-200 1 x 10 mg
BQ788 sodium salt
 		B-176 1 x 5 mg
FR 139317
 		F-180 1 x 10 mg
Sarafotoxin S6b
 		SPE-160 1 x 1 mg
Scientific Background
Scientific Background

The endothelin system is comprised of three active peptides, ET-1, 2, and 3, which are considered to be very powerful vasoconstrictive substances. In humans, endothelins mediate their actions via two specific G-Protein Coupled Receptors, ETAR and ETBR. Both ETAR and ETBR are present in heart and in human myocardium at similar levels1,2.

The endothelin receptors differ in their ligand specificity. While ETAR has varying affinities for the endothelin isoforms (ET-1 >ET-2>ET-3), ETBR shows no selective affinity.2,3 Subsequent studies have demonstrated the presence of endothelins in vascular as well as in non-vascular cells and tissues, having multiple biological activities.
References
  1. Davenport, A.P. (2002) Pharmacol. Rev. 54, 219.
  2. Boivin, B. et al. (2003) J. Biol.Chem. 278, 29153.
  3. Grant, K. et al. (2003) Br. J. Cancer. 88, 163.
Related Products
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  4. Endothelin Receptor Antagonist Explorer Kit (#EK-256)
  5. Endothelin Receptor Pharmacology Explorer Kit (#EK-257)