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Endothelin Receptor Basic Research Pack

All You Need for Endothelin Receptors Research
  • Lyophilized Powder
  • Antigen Incl.
Cat #: ESB-940
Sizes: 12 Vials
Last update: 01/07/2019

Endothelin Receptor Basic Research Pack (#ESB-940) contains all you need for Endothelin Receptor research: Antibodies for each receptor and selective pharmacological tools, all in one budget friendly package!

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Antibodies
Anti-Endothelin Receptor A Antibody
 		AER-001 1 x 0.2 ml
Anti-Endothelin Receptor B Antibody
 		AER-002 1 x 0.2 ml
Activators/Agonists
BQ-3020
 		SPE-200 1 x 10 mg
Sarafotoxin S6b
 		SPE-160 1 x 1 mg
Blockers/Antagonists
A-192621
 		A-360 1 x 10 mg
ACT-132577
 		A-350 1 x 10 mg
Bosentan hydrate
 		B-170 1 x 250 mg
BQ-123 sodium salt
 		B-185 1 x 10 mg
BQ788 sodium salt
 		B-176 1 x 5 mg
FR 139317
 		F-180 1 x 10 mg
Scientific Background

    • The endothelin system is comprised of three active peptides, ET-1, 2, and 3, which are considered to be very powerful vasoconstrictive substances. In humans, endothelins mediate their actions via two specific G-Protein Coupled Receptors, ETAR and ETBR. Both ETAR and ETBR are present in heart and in human myocardium at similar levels1,2.

      The endothelin receptors differ in their ligand specificity. While ETAR has varying affinities for the endothelin isoforms (ET-1 >ET-2>ET-3), ETBR shows no selective affinity.2,3 Subsequent studies have demonstrated the presence of endothelins in vascular as well as in non-vascular cells and tissues, having multiple biological activities.
      1. Davenport, A.P. (2002) Pharmacol. Rev. 54, 219.
      2. Boivin, B. et al. (2003) J. Biol.Chem. 278, 29153.
      3. Grant, K. et al. (2003) Br. J. Cancer. 88, 163.
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