Agon®, Plendil®, Renedil®
A Potent and Selective Blocker of L-Type CaV Channels
    Cat #: F-105
    Alternative Name Agon®, Plendil®, Renedil®
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 384.25
    Purity: >99%
    Effective concentration 1-10 μM.
    • Felodipine
    Chemical name 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5 pyridinedicarboxylic acid ethyl methyl ester.
    Molecular formula C18H19Cl2NO4.
    CAS No.: 72509-76-3.
    Activity Felodipine is a dihydropyridine that acts as L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat hypertension1,2.
    1. Furukawa, T. et al. (1999) J.P.E.T. 291, 464.
    2. Furukawa, T. et al. (2005) J. Cardiovasc. Pharmacol. 45, 241.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Felodipine
      Alomone Labs Felodipine blocks L-type Ca2+ currents in Xenopus oocytes.
      Superimposed current traces of L-type channels (CaV1.2+α2δ1+β1a), before and during applications of 1 and 10 μM Felodipine (#F-105) as indicated on the left. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to +10 mV.
    References - Scientific background
    1. Hockerman, G. H. et al. (1997) Annu. Rev. Pharmacol. Toxicol. 37, 361.
    2. Haller, H. (2008) Int. J. Clin. Pract. 62, 781.
    3. Furukawa, T. et al. (1999) J.P.E.T. 291, 464.
    4. Furukawa, T. et al. (2005) J. Cardiovasc. Pharmacol. 45, 241.
    5. Hagiwara, S. et al. (1993) Euro. J. Pharmacol. 234, 1.
    Scientific background

    L-type (CaV1), voltage-gated Ca2+ channels are plasma membrane protein complexes which allow the passage of Ca2+ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases1,2.

    Dihydropyridines (DHP) are molecules that act as allosteric modulators of L-type channels and many are used in the clinic to treat hypertension2. Felodipine is a DHP that acts as L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat hypertension2. Felodipine is used as a pharmacological tool to specifically target L-type channels in expression systems3,4 as well as in physiological preparations5. The effective concentration of felodipine varies between systems for example; it is higher for inhibition of smooth muscle high K+ induced contraction than for inhibition of the intracellular Ca2+ elevation in these cells5.

    Target L-type Ca2+ channels
    Last update: 24/01/2020

    Felodipine (#F-105) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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