Overview
Alternative Name Bladderon®, piperidinoethyl-3-methylflavone-8-carboxylate, Urispas®
Lyophilized Powder yes
Source Synthetic
MW: 427.9
Purity: >96%.
Effective concentration 1-100 µM.
Structure
Chemical name 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester hydrochloride.
Molecular formula C24H26NO4Cl.
CAS No.: 3717-88-2
Activity Flavoxate caused a concentration-dependent reduction of the K+-induced contraction of human urinary bladder. In human detrusor myocytes, flavoxate inhibited the peak amplitude of voltage-dependent nifedipine-sensitive inward Ba2+ currents in a voltage- and concentration-dependent manner (Ki 10 µM), and shifted the steady-state inactivation curve of Ba2+ currents to the left at a holding potential of -90 mV1.
References-Activity
- Tomoda, T. et al. (2005) Br. J. Pharmacol. 146, 25.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Flavoxate hydrochloride inhibits voltage-gated CaV1.2 currents heterologously expressed in Xenopus oocytes.A. Time course of CaV1.2/α2-δ1/β2a (L-type) current inhibition by 100 µM Flavoxate hydrochloride (#F-140). Currents were elicited by application of voltage steps from a holding potential of -100 mV to 0 mV (100 msec). B. Superimposed example traces of current responses before and during perfusion of 100 µM Flavoxate hydrochloride as indicated.
Target L-type Ca2+ channels
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
