Flunarizine dihydrochloride

Sibelium®
A Potent Blocker of L-type and T-type CaV Channels
    Cat #: F-110
    Alternative Name Sibelium®
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 477.4
    Purity: >99% (HPLC)
    Effective concentration 1-200 μM.
      • Flunarizine dihydrochloride
    Chemical name (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride.
    Molecular formula C26H26F2N2*2HCl.
    CAS No.: 30484-77-6.
    Activity Flunarizine dihydrochloride is a diphenylmethylpiperazine L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat migraine1. Flunarizine dihydrochloride inhibits L- and T-type CaV channels in guinea pig ventricular cells with similar potency and in a use-dependent manner2.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • Flunarizine dihydrochloride
        Alomone Labs Flunarizine dihydrochloride blocks L-type Ca2+ currents in Xenopus oocytes.
        A. Time course of L-type channel (CaV1.2+α2δ1+β1a) activity before and during applications of 10 and 100 μM Flunarizine dihydrochloride (#F-110) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV. Periods of compound application are indicated by the horizontal bars. B. Example of superimposed current traces before and during application of 10 and 100 μM Flunarizine dihydrochloride (taken from the experiment described in A).
    References - Scientific background
      • L-type (CaV1), voltage-gated Ca2+ channels are plasma membrane protein complexes which allow the passage of Ca2+ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases1,2.

        Flunarizine dihydrochloride is a diphenylmethylpiperazine L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat migraine3. Flunarizine dihydrochloride inhibits L- and T-type CaV channels in guinea pig ventricular cells with similar potency and in a use dependent manner4.

    Target L-type and T-type Ca2+ channels
    Last update: 23/09/2019

    Flunarizine dihydrochloride (#F-110) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Citations
    Related Products