Forskolin

Colforsin, Coleonol
An Adenylate Cyclase Activator
    Cat #: F-500
    Alternative Name Colforsin, Coleonol
  • Lyophilized Powder
  • Bioassay Tested
  • Origin Coleus forskohlii.
    Source Natural
    MW: 410.5
    Purity: >97% (HPLC)
    Effective concentration 5-10 μM.
      • Forskolin
    Chemical name [3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(Acetyloxy)-3-e thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pent amethyl-1H-naphtho[2,1-b]pyran-1-one.
    Molecular formula C22H34O7.
    CAS No.: 66575-29-9.
    Activity Forskolin increases cAMP levels by activating adenylate cyclase1.
      • Awad, J.A. et al. (1983) J. Biol. Chem. 258, 2960.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO, ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four months at 4°C.
      • Forskolin
        Alomone Labs Forskolin activates (in vivo) adenylate cyclase in NIH/C6 neuroblastoma cells.
        Cells were pre-incubated for 30 min with IBMX (10 mM) and then stimulated for 30 min with different concentrations of Forskolin (#F-500). Cellular cAMP levels were measured by an ELISA kit.
    References - Scientific background
      • Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii. Forskolin has a unique ability to stimulate adenylate cyclase activity and increase cyclic adenosine monophosphate (cAMP)1-10.
    Last update: 21/07/2019

    Forskolin (#F-500) is a highly pure, natural, and biologically active compound.

    For research purposes only, not for human use
    Citations
      • Palma, A.G. et al. (2016) Pflugers Arch. 468, 871.
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