GABA Transporter Antibody Explorer Kit

A Screening Package of GABA Transporter Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-435
Sizes: 14 Vials
Last update: 03/09/2018

Alomone Labs is pleased to offer the GABA Transporter Antibody Explorer Kit (#AK-435). The Explorer Kit contains GABA transporter antibodies, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Note A guinea pig polyclonal antibody (#AGP-129) is included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

γ-aminobutiric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Transmission via GABA can be halted by its reuptake through GABA transporters (GATs). These membrane proteins belong to the super family of slc6 genes which encode transporters responsible for the uptake of dopamine, serotonin, norepinephrine, glycine and GABA in a Na+-dependent manner1,2.

To date, four GATs have been identified: GAT-1GAT-2GAT-3 and BGT-1. Like all members of the slc6 family, they have twelve transmembrane domains and short intracellular N- and C-termini1. GATs couple the transport of one GABA molecule to 2Na+ ions and one Cl- ion3. GAT-1 activity can be regulated at the level of its plasma membrane expression which is in part regulated by its trafficking via phosphorylation of residues in intracellular loops1.

References
  1. Gonzalez-Burgos, G. (2010) Adv. Pharmacol. 58, 175.
  2. Gether, U. et al. (2006) Trends Pharmacol. Sci. 27, 375.
  3. Meinild, A.K. et al. (2009) J. Biol. Chem. 284, 16226.
Related Products