Every lot is tried & tested in a relevant biological assay.
- Alomone Labs Gambogic acid inhibits the proliferation of K562 human chronic myelogenous leukemia cells.Dose-response curve of Gambogic acid (#G-250) inhibition of K562 cell viability. Cell viability was determined by the XTT method and normalized to control. IC50 was calculated at 284 nM.
Gambogic acid is a compound originally derived from the gamboges resin of the tree, Garcinia hanburyi. Gambogic acid has been shown to pose cytotoxic activity against tumor cells in culture through a mechanism involving apoptosis1.
Gambogic acid was found to act as a slow blocker of Kir2.1 with relatively potent IC50 values of 100 nM and lower2.
Gambogic acid is better known for its agonistic action on caspases, proteases involved in apoptosis and as a Bcl-2 inhibitor. Bcl-2-family proteins are regulators of apoptosis1.
Gambogic acid (#G-250) is a highly pure, synthetic, and biologically active compound.