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ICA-110381

An Opener of KCNQ Channels

Cat #: I-160
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 267.1
    Purity: >99%
    Effective concentration 0.1-10 µM.
    Structure
    Chemical name 4-chloro-N-(6-chloropyridin-3-yl)benzamide.
    Molecular formula C12H8Cl2N2O.
    CAS No.: 325457-99-6
    PubChem CID 4314115
    Activity ICA-110381 is a KCNQ channel opener with anti-convulsive properties1.
    References-Activity
    1. Boehlen, A. et al. (2013) Br. J. Pharmacol. 168, 1182.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs ICA-110381 enhances KCNQ2/KCNQ3 heteromeric channels expressed in Xenopus oocytes. 
      Alomone Labs ICA-110381 enhances KCNQ2/KCNQ3 heteromeric channels expressed in Xenopus oocytes. 
      A. Time course of KCNQ2/KCNQ3 current enhancement by 0.2 and 1 µM ICA-110381 (#I-160). Currents were elicited by application of voltage step from a holding potential of -100 mV to +60 mV (700 msec). B. Superimposed example traces of current responses before and during perfusion of 0.2 and 1 µM ICA-110381, as indicated.
    References - Scientific background
    1. Schwake, M. et al. (2006) J. Neurosci. 26, 3757.
    2. Howard, R.J. et al. (2007) Neuron. 53, 663.
    3. Boehlen, A. et al. (2012) Br. J. Pharmacol. 168, 1182.
    Scientific background

    KV7 or KCNQs are voltage-gated K+ channels. These channels are mainly responsible for the cardiac and auditory IK currents and the neuronal M-current but can be found in other tissues as well. Voltage-gated K+ channels are tetramers of α-subunits, which surround a K+-selective pore1. The different five KCNQ subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain tail. This domain is a self-assembling, parallel, four-stranded coiled coil2.

    ICA-110381 is a synthetic opener of KCNQ channels with an effective concentration of 0.1μM-10μM. In hippocampal CA1 cells, ICA-110381 reduces cell membrane excitability caused by hyperpolarization and decreases membrane resistance. It exhibits strong anticonvulsant properties by acting mainly on the KCNQ2 subunit of the KV7 channel and reduces seizure severity and frequency3.

    Target KCNQ channels
    Lyophilized Powder
    Last update: 11/04/2021

    ICA-110381 (#I-160) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
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