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IEM-1921

1-Phenylcyclohexylamine, 4-Amino-4-phenylcyclohexane, PCA, 1-phenylcyclohexan-1-amine

NMDA Receptor Channel Blocker

Cat #: I-180
Alternative Name 1-Phenylcyclohexylamine, 4-Amino-4-phenylcyclohexane, PCA, 1-phenylcyclohexan-1-amine
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 175.27
    Purity: >99% (HPLC)
    Form Lyophilized Powder
    Effective concentration 1-10 µM
    Structure
    Chemical name 1-phenylcyclohexan-1-amine
    Molecular formula C12H17N
    CAS No.: 2201-24-3
    PubChem CID 31862
    Activity IEM-1921 is a selective NMDA receptor blocker and is a potent anticonvulsant 1-3.
    References-Activity
    1. Bolshakov, K.V. et al. (2005) Neuropharm., 49, 144.
    2. Bolshakov, K.V. et al. (2003) J. Neurochem., 87, 56.
    3. Zaitsev, A.V. et al. (2015) J. Neurosci. Res., 93, 454.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in DMSO
    Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs IEM-1921 inhibits NMDA (NR1+NR2A) receptors expressed in Xenopus oocytes.
      Alomone Labs IEM-1921 inhibits NMDA (NR1+NR2A) receptors expressed in Xenopus oocytes.
      A. Representative time course of NR1/NR2A currents, elicited by transient stimulations with 20 µM glutamate + 20 µM glycine every 50 sec, while membrane potential was held at -60 mV, and significantly inhibited by 10 μM IEM-1921 (#I-180).
      B. Superimposed current traces from the recording shown in A, following application of control and 10 μM IEM-1921. Transient stimulation is indicated by an arrow.
    References - Scientific background
    1. Liu, J. et al. (2019) Front. Neurosci.,13, 43.
    2. Zaitsev A.V. et al. (2015) J. Neurosci. Res., 93, 454.
    3. Vataev S.I. et al. (2020) Neurosci. Behav. Physi., 50, 374.
    Scientific background

    N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an important role in the central nervous system. Activation of NMDARs leads to cytosolic free intracellular calcium ([Ca2+]i) increase and for synaptic plasticity1.

    Abnormal activity of NMDA receptors is associated different neurodegenerative disorders such as Alzheimer’s, Huntington’s, Parkinson’s disease and the etiology of epilepsy1.

    IEM-1921, also known as 1-phenylcyclohexylamine, is a selective blocker of NMDA receptors. In chronic experiments on Wistar and Krushinskii–Molodkina rats it was found that IEM-1921 (5mg/kg) acts as anticonvulsant. IEM-1921 decreased the duration of convulsions by 82% and prevent neural abnormalities in the brain2-3.

    Target NMDA receptor
    Last update: 16/11/2021

    IEM-1921 (#I-180) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use

    Applications

    Specifications

    Scientific Background

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