- Lyophilized Powder Lyophilized Powder
This product is freeze dried. All water molecules have been removed.
- Antigen Incl. Control Antigen Included
This antibody is shipped with its antigen FREE of charge!
- QC Tested QC Tested
The activity of this product has been verified and approved by our professional team.
- Shipped at Room Temp. Shipped at Room Temp.
This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
Alomone Labs is pleased to offer the Intracellular Cl– Channel (CLIC) Antibody Explorer Kit (#AK-410). This Explorer Kit includes intracellular Cl– channel (CLIC) antibodies with their respective peptide control antigen. An ideal tool for screening purposes.
Chloride intracellular channel (CLIC) is a family of proteins encoded by six different genes (CLIC1-6)1-3.
The localization of the various CLIC channels remains elusive and controversial since they can be either found in a soluble form in the cytoplasm or as integral membrane proteins (in intracellular compartments such as the nuclear membrane or the endoplasmic reticulum for example, or associate to the plasma membrane) via their single transmembrane domain1.
When membrane associated, CLIC channels indeed function as ion channels (enabling the passage of Cl- ions).
Non-channel functions are also attributed to CLICs and include cell cycle regulation, cell differentiation, and apoptosis. These different roles depend whether CLICs are membrane bound or cytosolic1.