- Lyophilized Powder Lyophilized Powder
This product is freeze dried. All water molecules have been removed.
- Antigen Incl. Control Antigen Included
This antibody is shipped with its antigen FREE of charge!
Alomone Labs is pleased to offer the Kainate Receptor Antibody Explorer Kit (#AK-555). The Explorer Kit contains kainate receptor antibodies, ideal for screening purposes.
|Product Name||Cat #||Size|
Anti-GRIK1 (GluK1) (extracellular) Antibody
|AGC-008||1 x 50 µl|
Anti-GRIK2 (GluK2) Antibody
|AGC-009||1 x 50 µl|
Anti-GRIK3 (GluK3) (extracellular) Antibody
|AGC-040||1 x 50 µl|
Anti-GRIK4 (KA1) (extracellular) Antibody
|AGC-041||1 x 50 µl|
Anti-GRIK5 (GluK5) (extracellular) Antibody
|AGC-042||1 x 50 µl|
The kainate receptor subfamily consists of five members that have been further subdivided into two classes based upon structural homology and functional characteristics. GluR5, GluR6, and GluR7 receptor subunits share a high degree of homology and are able to form functional channels when expressed in heterologous systems. The KA-1 and KA-2 receptors are unable to form functional channels on their own, but when coexpressed with GluR5-7 receptor subunits, they form channels with high affinity for kainate.1,2
Like AMPA receptors, the functional unit of endogenous kainate receptors is believed to be a tetramer, which can be either homomeric or heteromeric. Kainate receptors GluR5 and GluR6 (but not GluR7, KA-1, or KA-2) can undergo RNA editing; as in the AMPA receptor GluR2, a glutamine (Q) residue in the channel pore is edited to encode arginine (R) in the mature protein. Substitution of Q with R modulates the properties of the channel, producing channels with reduced single channel conductance and lower permeability to Ca2+.1,2