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Certificate of Analysis

  • Bioassay Tested

KCa Channel Opener Explorer Kit

A Screening Package of KCa Channel Openers Economically Priced

Cat #: EK-201
Size: 11 Vials
Form: Lyophilized

CyPPA Cat #: C-110

Size: 5 mg Source: Synthetic MW: 285.4 Purity: >98%
Effective concentration
1-100 μM.
Activity
CyPPA is an activator of small conductance Ca2+-activated K+ channels KCa2.2 (SK2) and KCa2.3 (SK3) with EC50 values of 5.6 and 14 μM for SK3 and SK2 respectively. It displays no activity at SK1 and intermediate conductance KCa (IK) channels1. CyPPA blocks TRPM7 channels2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

1-EBIO Cat #: E-150

Size: 10 mg Source: Synthetic MW: 162.19 Purity: >97%
Effective concentration
5-100 μM.
Activity
1-EBIO is an activator of KCa3.1 and KCa2 channel currents1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
250 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Isopimaric Acid Cat #: I-370

Size: 1 mg Source: Natural MW: 302 Purity: >99%
Origin
Natural product of unspecified plant origin.
Effective concentration
1-100 μM.
Activity
Isopimaric acid is a potent opener of large conductance Ca2+-activated K+ (BK) channels. 1 μM of Isopimaric acid doubles the current carried via BK channels. Isopimaric acid may increase the open probability by shifting the Ca2+ and voltage dependence to more hyperpolarized voltages1. The sensitivity is decreased in the Xenopus system compared to mammalian cells. BK channels activated by Isopimaric acid retain their charybdotoxin sensitivity.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO, ethanol, acetone or methanol. DMSO is suggested for biological experiments. DMSO solution should not exceed 0.03%. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

NS-11021 Cat #: N-335

Size: 5 mg Source: Synthetic MW: 511.24 Purity: >99%
Effective concentration
0.5-50 µM.
Activity
NS-11021 is a potent KCa1.1 channel agonist, enhancing KCa1.1 currents with EC50 of 0.4 µM, whilst having no effect on a variety of K+, Na+ and Ca2+ channels at 10 µM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

NS-1619 Cat #: N-105

Size: 5 mg Source: Synthetic MW: 362.2 Purity: >95%
Effective concentration
100 nM - 100 μM.
Activity
NS-1619 is a potent and selective KCa1.1 (BK, slo, Large conductance Ca2+-activated K+) channel modulator (enhancer)1. NS-1619 was effective in eliciting and enhancing KCa1.1 channels in smooth muscle as well as in neurons with maximal effects at concentrations around 30 μM1,2. NS-1619 was used in vivo by intracarotid infusion and significantly enhanced blood tumor barrier permeability in the brain tumor area but not in normal brain tissue3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

NS19504 Cat #: N-235

Size: 5 mg Source: Synthetic MW: 269.2 Purity: >99%
Effective concentration
5 µM – 100 µM.
Activity
NS19504 is a KCa1.1 channel opener1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

NS-309 Cat #: N-180

Size: 5 mg Source: Synthetic MW: 231.04 Purity: >99% (HPLC)
Effective concentration
0.1 - 10 µM.
Activity
NS-309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ (KCa2 and KCa3.1) channels, with EC50 values of 30 and 10 nM, respectively1. NS-309 also blocks L-type Ca2+ channels with IC50 value of 10 μM2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Pimaric Acid Cat #: P-270

Size: 1 mg Source: Natural MW: 302 Purity: >85%
Origin
Natural product of unspecified plant origin.
Effective concentration
1-10 µM.
Activity
Pimaric acid is a potent opener of large conductance Ca2+-activated K+ (BK) channels. 1 µM of Pimaric acid doubles the current carried via BK channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Organic solvents such as DMSO, ethanol, acetone or methanol. DMSO is suggested for biological experiments. DMSO solution should not exceed 0.03%. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

SKA-31 Cat #: S-120

Size: 5 mg Source: Synthetic MW: 200.2 Purity: >98%
Effective concentration
0.1-10 µM.
Activity
SKA-31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively)1. Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice1,2. SKA-31 blocks TRPM73.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

SKA-121 Cat #: S-245

Size: 5 mg Source: Synthetic MW: 198.22 Purity: >97%(HPLC)
Effective concentration
100 nM - 10 µM
Activity
SKA-121 is a positive gating modulator of KCa3.1 channels (EC50 of 109 nM), potent and selective over KCa2 subtypes (EC50 of 4.4-8.7 μM). Significantly lowers mean arterial blood pressure in vivo in wild-type hypertensive mice (100 mg/kg i.p.)1.
Storage before reconstitution
Store at -20°C.
Reconstitution
Soluble in DMSO. Spin down all products before handling.
Storage after reconstitution
Store at -20°C. It is recommended to aliquot stock solutions to avoid repeated thawing and freezing.

Tanshinone II-A sodium sulfonate Cat #: T-165

Size: 5 mg Source: Synthetic MW: 396.4 Purity: ≥98%
Effective concentration
10-200 µM.
Activity
Tanshinone II-A sodium sulfonate  is a KCa1.1 channel opener1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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