K_Ca2-Related Channel Modulator Explorer Kit

K_Ca2 channels are extremely sensitive to the levels of intracellular Ca²⁺ and concentrations as low as 300-700 nM can open these channels very rapidly (5-15 ms). Hence, the K_Ca2 channels are highly sensitive and fast Ca²⁺ sensors, resembling other known Ca²⁺-binding proteins. This type of Ca²⁺-dependent activation is achieved by the constitutive binding of the K_Ca2 channels to calmodulin, a highly expressed Ca²⁺-binding protein via a calmodulin-binding domain situated at the cytoplasmic C-terminus.

Pharmacologically, the K_Ca2 channels are the only known targets of the bee venom toxin Apamin, with K_Ca2.1 being the less sensitive, K_Ca2.2 the most sensitive and K_Ca2.3 showing intermediate sensitivity.