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Certificate of Analysis

  • Bioassay Tested

KCNN4 (KCa3.1, SK4) Channel Modulator Explorer Kit

A Screening Package of KCNN4 Channel Modulators Economically Priced

Cat #: EK-133
Size: 9 Vials
Form: Lyophilized

1-EBIO Cat #: E-150

Size: 10 mg Source: Synthetic MW: 162.19 Purity: >97%
Effective concentration
5-100 μM.
Activity
1-EBIO is an activator of KCa3.1 and KCa2 channel currents1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
250 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Maurotoxin Cat #: STM-340

Size: 0.1 mg MW: 3612 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-200 nM.
Activity
Maurotoxin activity was extensively assayed on a large array of K+ channels, including KCa (KCa1.1, KCa2.1, KCa2.2, KCa2.2, KCa3.1), KCNA (KCNA1, KCNA2 and KCNA3) and Shaker-B K+ currents and seems to be very potent blocker of either KCa3.1 and KCNA2 channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

NS-309 Cat #: N-180

Size: 5 mg Source: Synthetic MW: 231.04 Purity: >99% (HPLC)
Effective concentration
0.1 - 10 µM.
Activity
NS-309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ (KCa2 and KCa3.1) channels, with EC50 values of 30 and 10 nM, respectively1. NS-309 also blocks L-type Ca2+ channels with IC50 value of 10 μM2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

NS-4591 Cat #: N-325

Size: 5 mg Source: Synthetic MW: 258.03 Purity: >98% (HPLC)
Effective concentration
0.01-5 μM.
Activity
NS-4591 is a potent SK4 channel activator; 30 nM doubled KCa3.1 currents in HEK cells1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

NS-6180 Cat #: N-230

Size: 5 mg Source: Synthetic MW: 323.3 Purity: >98%
Effective concentration
10 nM – 1 μM.
Activity
NS-6180 blocks SK4 channels with IC50 of  9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

OsK-1 Toxin Cat #: STO-150

Size: 0.1 mg MW: 4205 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
5-100 nM.
Activity
OsK-1 inhibits KV1.1, KV1.2, KV1.3 channels potently and KCa3.1 channel moderately1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer.
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.

SKA-31 Cat #: S-120

Size: 5 mg Source: Synthetic MW: 200.2 Purity: >98%
Effective concentration
0.1-10 µM.
Activity
SKA-31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively)1. Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice1,2. SKA-31 blocks TRPM73.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

SKA-121 Cat #: S-245

Size: 5 mg Source: Synthetic MW: 198.22 Purity: >97%(HPLC)
Effective concentration
100 nM - 10 µM
Activity
SKA-121 is a positive gating modulator of KCa3.1 channels (EC50 of 109 nM), potent and selective over KCa2 subtypes (EC50 of 4.4-8.7 μM). Significantly lowers mean arterial blood pressure in vivo in wild-type hypertensive mice (100 mg/kg i.p.)1.
Storage before reconstitution
Store at -20°C.
Reconstitution
Soluble in DMSO. Spin down all products before handling.
Storage after reconstitution
Store at -20°C. It is recommended to aliquot stock solutions to avoid repeated thawing and freezing.

TRAM 34 Cat #: T-105

Size: 5 mg Source: Synthetic MW: 344.8 Purity: >99%
Effective concentration
10 nM - 1 μM.
Activity
TRAM 34 is a potent and selective KCa3.1 (SK4, intermediate conductance Ca2+-activated K+) channel inhibitor1. As such, it is a powerful pharmacological tool that enables the determination of the roles played by KCa3.1 channels in different physiological systems ranging from activation of T lymphocytes to migration of endothelial cells2-3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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