Overview
KCNQ (KV7) Channel Basic Research Pack (#ESB-503) contains all you need for KCNQ channel research: Antibodies for each channel and KV7 selective pharmacological tools, all in one budget friendly package!
Compounds
| Product Name | Cat # | Size |
|---|---|---|
| Antibodies | ||
Anti-KCNQ1 Antibody |
APC-022 | 1 x 0.2 ml |
KCNQ1 Blocking Peptide |
BLP-PC022 | 1 x 40 µg |
Anti-KCNQ2 Antibody |
APC-050 | 1 x 0.2 ml |
KCNQ2 Blocking Peptide |
BLP-PC050 | 1 x 40 µg |
Anti-KCNQ3 Antibody |
APC-051 | 1 x 0.2 ml |
KCNQ3 Blocking Peptide |
BLP-PC051 | 1 x 40 µg |
Anti-KCNQ4 Antibody |
APC-164 | 1 x 0.2 ml |
KCNQ4 Blocking Peptide |
BLP-PC164 | 1 x 40 µg |
Anti-KCNQ5 Antibody |
APC-155 | 1 x 0.2 ml |
KCNQ5 Blocking Peptide |
BLP-PC155 | 1 x 40 µg |
| Activators/Agonists | ||
2,5-dimethylcelecoxib |
D-150 | 1 x 25 mg |
| Blockers/Antagonists | ||
Linopirdine dihydrochloride |
L-156 | 1 x 25 mg |
XE991 dihydrochloride |
X-101 | 1 x 25 mg |
| Modulators | ||
Retigabine dihydrochloride |
R-101 | 1 x 50 mg |
Scientific Background
The KCNQ (KV7) family of channels consists of five members (KV7.1, KV7.2, KV7.3, KV7.4 and KV7.5). KCNQ channels commonly display activation at voltages close to neuronal resting membrane potentials and are regulated by G-protein coupled receptor (GPCR) signaling, notably by muscarinic receptors1.
KCNQ family members can form either homomultimeric or heteromultimeric channels with different functional consequences. For example, KCNQ2 and KCNQ3 heteromultimers give rise to a much larger channel current than when expressed alone. Probably due to enhanced plasma membrane expression of the combined channel. Indeed, KCNQ2/KCNQ3 heteromultimers are believed to be the molecular correlates of the so-called M current2-4.
- Brown, D.A. and Adams, P.R. (1980) Nature 283, 673.
- Kullmann, D.M. (2002) J. Mol. Brain 125, 1117.
- Robbins, J. (2001) Pharmacol. Ther. 90, 1.
- Wang, H.S. et al. (1998) Science 282, 1890.
