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KCNQ (KV7) Channel Basic Research Pack

All You Need for KCNQ (KV7) Channels Research
  • Lyophilized Powder
  • Antigen Incl.
Cat #: ESB-503
Sizes: 15 Vials
Last update: 23/04/2019

KCNQ (KV7) Channel Basic Research Pack (#ESB-503) contains all you need for KCNQ channel research: Antibodies for each channel and KV7 selective pharmacological tools, all in one budget friendly package!

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Anti-KCNQ1 Antibody
 		APC-022 1 x 0.2 ml
Anti-KCNQ2 Antibody
 		APC-050 1 x 0.2 ml
Anti-KCNQ3 Antibody
 		APC-051 1 x 0.2 ml
Anti-KCNQ4 Antibody
 		APC-164 1 x 0.2 ml
Anti-KCNQ5 Antibody
 		APC-155 1 x 0.2 ml
2,5-dimethylcelecoxib
 		D-150 1 x 25 mg
Flupirtine Maleate
 		F-150 1 x 25 mg
Linopirdine dihydrochloride
 		L-156 1 x 25 mg
Retigabine dihydrochloride
 		R-101 1 x 50 mg
XE991 dihydrochloride
 		X-101 1 x 25 mg
Scientific Background
Scientific Background

The KCNQ (KV7) family of channels consists of five members (KV7.1, KV7.2, KV7.3, KV7.4 and KV7.5).  KCNQ channels commonly display activation at voltages close to neuronal resting membrane potentials and are regulated by G-protein coupled receptor (GPCR) signaling, notably by muscarinic receptors1.

KCNQ family members can form either homomultimeric or heteromultimeric channels with different functional consequences. For example, KCNQ2 and KCNQ3 heteromultimers give rise to a much larger channel current than when expressed alone. Probably due to enhanced plasma membrane expression of the combined channel. Indeed, KCNQ2/KCNQ3 heteromultimers are believed to be the molecular correlates of the so-called M current2-4.
References
  1. Brown, D.A. and Adams, P.R. (1980) Nature 283, 673.
  2. Kullmann, D.M. (2002) J. Mol. Brain 125, 1117.
  3. Robbins, J. (2001) Pharmacol. Ther. 90, 1.
  4. Wang, H.S. et al. (1998) Science 282, 1890.
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