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KCNQ (KV7) Channel Basic Research Pack

All You Need for KCNQ (KV7) Channels Research
  • Lyophilized Powder
  • Antigen Incl.
Cat #: ESB-503
Sizes: 15 Vials
Last update: 10/09/2019

KCNQ (KV7) Channel Basic Research Pack (#ESB-503) contains all you need for KCNQ channel research: Antibodies for each channel and KV7 selective pharmacological tools, all in one budget friendly package!

For research purposes only, not for human use
Compounds
Product NameCat #Size
Antibodies
Anti-KCNQ1 Antibody
 APC-022 1 x 0.2 ml
Anti-KCNQ2 Antibody
 APC-050 1 x 0.2 ml
Anti-KCNQ3 Antibody
 APC-051 1 x 0.2 ml
Anti-KCNQ4 Antibody
 APC-164 1 x 0.2 ml
Anti-KCNQ5 Antibody
 APC-155 1 x 0.2 ml
Activators/Agonists
2,5-dimethylcelecoxib
 D-150 1 x 25 mg
Blockers/Antagonists
Linopirdine dihydrochloride
 L-156 1 x 25 mg
XE991 dihydrochloride
 X-101 1 x 25 mg
Modulators
Flupirtine Maleate
 F-150 1 x 25 mg
Retigabine dihydrochloride
 R-101 1 x 50 mg
Scientific Background

    • The KCNQ (KV7) family of channels consists of five members (KV7.1, KV7.2, KV7.3, KV7.4 and KV7.5).  KCNQ channels commonly display activation at voltages close to neuronal resting membrane potentials and are regulated by G-protein coupled receptor (GPCR) signaling, notably by muscarinic receptors1.

      KCNQ family members can form either homomultimeric or heteromultimeric channels with different functional consequences. For example, KCNQ2 and KCNQ3 heteromultimers give rise to a much larger channel current than when expressed alone. Probably due to enhanced plasma membrane expression of the combined channel. Indeed, KCNQ2/KCNQ3 heteromultimers are believed to be the molecular correlates of the so-called M current2-4.

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