Free shipping starts now, no minimum, no coupons required!

Certificate of Analysis

  • Bioassay Tested

Kir Channel Blocker Explorer Kit

A Screening Package of Kir Channel Blockers Economically Priced
Cat #: EK-112
Size: 9 Vials
Form: Lyophilized

Carvedilol Cat #: C-180

Size: 50 mg Source: Synthetic MW: 406.47 Purity: >97%
Effective concentration
0.1-300 µM.
Activity
Carvedilol is a blocker of KV1.5 channels with IC50 ~0.5 μM1. It also blocks Kir2.3 channels2 and antagonizes adrenoceptors3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100mM in DMSO . Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

δ-Dendrotoxin Cat #: D-380

Size: 70 µg MW: 6568 Da. Purity: >98% (HPLC) Net peptide content: 100%
Origin
Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).
Effective concentration
10-100 nM.
Activity
δ-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated K+ channels (KV1.1, KV1.2 and KV1.6). In addition δ-Dendrotoxin inhibits ROMK1 channel currents.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Lq2 Cat #: RTL-550

Size: 5 µg MW: 4353 Da. Purity: >98% (HPLC) Net peptide content: 100%
Origin
Recombinant, E. coli
Effective concentration
0.1-10 nM.
Activity
Lq2 inhibits Kir1.1 Kinward rectifier channels2, as well as KCa channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

Rosiglitazone Cat #: R-125

Size: 10 mg Source: Synthetic MW: 357.43 Purity: >97%
Effective concentration
2-200 µM.
Activity
Rosiglitazone blocks KV4.3 channels with an IC50 = 24.5 μM1, Kir6.1 channels with as IC50 = 2 μM2 and blocks TRPM3 channels with IC50 = 5-10 μM3. At high concentrations Rosiglitazone activates TRPC5 channels3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO . Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Tertiapin Cat #: STT-250

Size: 0.1 mg MW: 2455 Da. Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10-100 nM.
Activity
Tertiapin blocks a range of inward rectifier K+ channels (Kir) in particular ROMK1 and GIRK but with no effect on Kir2 family members1. In addition, it was shown to inhibit acetylcholine induced K+ currents in the heart2,3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

Tertiapin-LQ Cat #: STT-220

Size: 0.5 mg MW: 2428 Da. Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
100 nM.
Activity
Tertipain-LQ is a selective blocker of Kir1.1 channels.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

Tertiapin-Q Cat #: STT-170

Size: 0.1 mg MW: 2452 Da. Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
2-200 nM.
Activity
Tertiapin-Q blocks a range of inward rectifier K+ channels (Kir), in particular ROMK1 and GIRK, but with no effect on Kir2 family members1. In addition, it was shown to inhibit acetylcholine induced K+ currents in heart2,3. Tertiapin-Q is a derivative of Tertiapin in which Met13 is replaced by Gln. Tertiapin-Q inhibits the above-mentioned channels with similar affinities4.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.

VU590 dihydrochloride Cat #: V-130

Size: 5 mg Source: Synthetic MW: 561.46 Purity: >98% (HPLC)
Effective concentration
0.1-25 µM.
Activity
VU590 inhibits ROMK1 channels in a dose-dependent manner with an IC50 of 294 nM. Inhibits Kir7.1 at micromolar concentrations, whilst having no effect on Kir2.1 or Kir4.11.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

VU591 hydrochloride Cat #: V-126

Size: 5 mg Source: Synthetic MW: 404.8 Purity: ≥98.5%
Effective concentration
0.1-50 µM.
Activity
VU591 is a Kir1.1 channel blocker1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
Shipping and Ordering information