- Lyophilized Powder Lyophilized Powder
This product is freeze dried. All water molecules have been removed.
- Bioassay Tested Bioassay Tested
This antibody has undergone quality control and has been approved by our professional team.
Alomone Labs is pleased to offer the KV Channel Blockers for Pain Research Explorer Kit (#EK-380). The Explorer Kit contains KV channel blockers for pain research, ideal for screening purposes.
|Product Name||Cat #||Size|
|D-360||1 x 35 µg|
|D-390||1 x 0.14 mg|
|D-400||1 x 10 µg|
|STH-340||1 x 0.1 mg|
|STH-400||1 x 0.1 mg|
|L-156||1 x 5 mg|
|STM-250||1 x 0.5 mg|
|STP-700||1 x 50 µg|
|X-101||1 x 5 mg|
Voltage gated potassium channel subunits (KV) were found to be related to hyperexcitability of injured nerves and pain transduction The predominant KV1 channels in myelinated nerve fibers comprise of co-assembled KV1.1, KV1.2, and KV2.1 that form dendrotoxin (DTX)-sensitive delayed-rectifier channels. Interestingly, KV1.4 is the sole subunit expressed in small types of fibers such as Aδ and C1.
The trigeminal nerve has a predominant sensory function compared with that of other peripheral nerves such as sciatic nerve because it is predominantly composed of sensory afferents, and only contains a small number of efferent fibers thus demonstrating the neuropathic pain mechanism following a purely sensory nerve injury. Experiments in trigeminal neuropathic/inflammatory pain model indicate that the common activity of the KV channels, such as IA, IK in rats with neuropathic/inflammatory pain, are significantly suppressed compared to those in naïve rats.
Several types of KV channels have been proposed as potential target candidates for pain therapy. It has recently been demonstrated that a selective KCNQ/KV7 channel opener (Retigabine), which mediates M-currents, selectively reduces the activity of axotomized Aδ/C-fibers, but not uninjured axons and human C-fiber axons. In addition Retigabine could attenuate allodynia due to TMJ inflammation in rats2.
- KV Channel Antibodies for Pain Research Explorer Kit (#AK-385)
- K+ Channel Antibodies for Pain Research Explorer Kit (#AK-390)
- K+ Channel Blockers for Pain Research Explorer Kit (#EK-390)
- Classical Ion Channel Blockers for Pain Research Explorer Kit (#EK-355)
- Ion Channel Activators for Pain Research Explorer Kit (#EK-395)