KV1.3 (KCNA3) Channel Basic Research Pack

All You Need for KV1.3 (KCNA3) Channel Research
  • Lyophilized Powder
  • Antigen Incl.
Cat #: ESB-501
Sizes: 6 Vials
Last update: 23/04/2019

Alomone Labs is pleased to offer the KV1.3 (KCNA3) Channel Basic Research Pack (#ESB-501). The Research Pack contains all you need for KV1.3 research: Antibodies recognizing different domains of the channel and specific KV1.3 blockers, all in one economical package!

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Anti-KV1.3 (KCNA3) Antibody
APC-002 1 x 0.2 ml
Anti-KV1.3 (KCNA3) (extracellular) Antibody
APC-101 1 x 0.2 ml
Aa1 Toxin
RTA-400 1 x 10 µg
Agitoxin-2
STA-420 1 x 0.1 mg
Scientific Background
    • KV1.3 belongs to the Shaker family of voltage-dependent K+ channels. The channel, encoded by KCNA3, is widely expressed in the brain, lung and osteoclasts and in several cell populations of hematopoietic origin. It is in these cells (particularly T lymphocytes) that KV1.3 function has centered a lot of attention. It was found that KV1.3 is the main channel  

      Responsible for maintaining the resting potential in quiescent cells and regulating the Ca2+ signaling that is indispensable for normal T lymphocyte activation.1,2  

      Based on the central role of Kv1.3 in regulating the initiation of an immune response, the channel has been recognized as a potential target for immunosuppressant drugs.1 

      KV1.3 channels are potently inhibited by several venomous peptide toxins among them Charybdotoxin (#STC-325, 2.6 nM), Noxiustoxin (#STN-340, 1 nM), Kaliotoxin (#STK-370, 0.65 nM), Margatoxin (#STM-325, 0.05 nM), Agitoxin-1 (#RTA-150, 1.7 nM), Agitoxin-2 (#STA-420, 0.004 nM), Hongotoxin-1 (#RTH-400, 0.09 nM)  and Stichodactyla toxin (#STS-400, 0.01 nM).3-7

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