KV4 Channel Premium Research Pack

All You Need for KV4 Channel Research
  • Lyophilized Powder
  • Antigen Incl.
  • Bioassay Tested
  • QC Tested
  • Shipped at Room Temp.
  • Immuno-Colocalization
  • 100% Net Peptide
Cat #: ESP-502
Sizes: 11 Vials
Last update: 25/12/2017

Alomone Labs is pleased to offer the KV4 Channel Premium Research Pack (#ESP-502). The Research Pack contains all you need for KV4 research: Antibodies for each KV4 channels and specific KV4 blockers, all in one economical package!

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-KV4.1
APC-119 1 x 0.2 ml
Anti-KV4.2
APC-023 1 x 0.2 ml
Anti-KV4.3
APC-017 1 x 0.2 ml
Guinea pig Anti-KV4.2
AGP-038 1 x 0.2 ml
Dapoxetine hydrochloride
D-175 1 x 50 mg
Fluoxetine hydrochloride
F-155 1 x 250 mg
SNX-482
RTS-500 1 x 50 µg
Note A guinea pig polyclonal antibody (#AGP-038) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

KV4.2 is a voltage-dependent K+ channel that belongs to the Shal channel subfamily and includes two other members: KV4.1 and KV4.3.1

KV4.2 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N- and C- termini. As with other members of the voltage-gated K+ channel superfamily, the functional channel is a tetramer that can be composed of more than one member of the Shal subfamily, i.e. heterotetramers of KV4.1 and KV4.3.

The KV4 channels are characterized by activation at subthreshold membrane potentials, inactivate rapidly and recover from inactivation quickly compared with other voltage-dependent K+ channels. This type of current is known as transient A-type K+ currents. For example, depolarization-activated K+ currents in rat neostriatal cholinergic interneurons are predominantly of the A-type and attributable to coexpression of KV4.2 and KV4.1 subunits.2

The biophysical properties of the Kv4.2 subunit can be modified by its association with auxiliary β subunits such as the KChIP family that increase KV4.2 current densities and accelerates both the inactivation and the recovery time.

KV4.2 is also highly expressed in the heart where together with Kv4.3 underlie the fast inactivating and recovering cardiac transient outward current Ito.3

Several toxins from spider venoms are potent blockers (affecting the channels in the nanomolar range) of KV4.2 channels. Among these the most potent and selective are Stromatoxin-1 (#STS-350), (1.2 nM), Phrixotoxin-1 (#STP-700), (5 nM), Phrixotoxin-2 (#STP-710), (34 nM) and Heteropodatoxin-2 (#STH-340), (100 nM).4

References
  1. Serodio, P. et al. (1994) J. Neurophysiol. 72,1516.
  2. Tsaur, M.L. et al. (1997) FEBS Lett. 400, 215.
  3. Guo, W. et al. (2002) Circ. Res. 90, 586.
  4. Diochot, S. et al. (1999) Br. J. Pharmacol. 126, 251.
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