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Certificate of Analysis

  • Bioassay Tested

KCNQ (KV7) Channel Modulator Explorer Kit

A Screening Package of KCNQ (KV7) Channel Modulators Economically Priced

Cat #: EK-131
Size: 8 Vials
Form: Lyophilized

2,5-dimethylcelecoxib Cat #: D-150

Size: 5 mg Source: Synthetic MW: 395.4 Purity: >99%
Effective concentration
10 µM.
Activity
2,5-dimethylcelecoxib is a KCNQ channel opener in smooth muscle cells1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

ICA-27243 Cat #: I-130

Size: 5 mg Source: Synthetic MW: 268.64 Purity: >99%
Effective concentration
0.5-50 µM.
Activity
ICA-27243 is a potent and selective KCNQ channel modulator (enhancer)1 with EC50 ~ 1 µM.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

ICA-110381 Cat #: I-160

Size: 5 mg Source: Synthetic MW: 267.1 Purity: >99%
Effective concentration
0.1-10 µM.
Activity
ICA-110381 is a KCNQ channel opener with anti-convulsive properties1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Linopirdine dihydrochloride Cat #: L-156

Size: 5 mg Source: Synthetic MW: 464.39 Purity: >98%
Effective concentration
0.1-300 µM.
Activity
Linopirdine blocks KCNQ channels with an IC50 of 2.4 μM for KV7.2/3 heteromers1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

NS-1643 Cat #: N-115

Size: 10 mg Source: Synthetic MW: 380.2 Purity: >95%
Effective concentration
1-100 μM.
Activity
NS-1643 is a potent and selective KV11.1 (hERG, ERG1, erg1) channel modulator (enhancer)1. NS-1643 was effective in eliciting and enhancing KV11.1 channels in Xenopus oocytes with apparent EC50 of 20 μM1. NS-1643 inhibited smooth muscle from bovine epididymal duct contractions with EC50 values of 8 μM2. It also potentiates KCNQ2 but not KCNQ1 channels3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

QO-40 Cat #: Q-265

Size: 5 mg Source: Synthetic MW: 377.8 Purity: >99%
Effective concentration
1-100 µM.
Activity
QO-40 is a KCNQ channel opener with EC50 of ~7 µM on cloned channels and on native M-current in DRG neurons1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Retigabine dihydrochloride Cat #: R-101

Size: 10 mg Source: Synthetic MW: 376.2 Purity: >98%
Effective concentration
0.1-100 µM
Activity
Retigabine is a potent and selective KCNQ (KV7, M-) channel modulator (enhancer)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

XE991 dihydrochloride Cat #: X-101

Size: 5 mg Source: Synthetic MW: 449.37 Purity: >98%
Effective concentration
0.1-300 µM.
Activity
XE991 blocks KCNQ channels with IC50 of 0.5-10 µM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 50mM in water. Mild warming or agitation may be required. Spin-down all product preparations before handling.
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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