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L-701,324

7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone

An Antagonist of NMDA Receptors

Cat #: L-195
Alternative Name 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 363.8
    Purity: >97%
    Form Lyophilized Powder
    Effective concentration 2 nM – 0.1 µM
    Structure
    Chemical name 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
    Molecular formula C21H14CINO3
    CAS No.: 142326-59-8
    PubChem CID 54682505
    Activity L-701,324 is a potent and selective NMDA receptor antagonist that acts at the glycine site1,2.
    References-Activity
    1. Priestley, T. et al. (1996) Neuropharmacol. 35, 1573.
    2. Traynelis S. F. et al. (2010) Pharmacol. Rev., 62, 405,
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Protect from light and moisture.
    Solubility

    Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing. 

    Storage of solutions Store up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs L-701,324 inhibits NMDA (NR1+NR2A) receptors expressed in Xenopus oocytes.
      Alomone Labs L-701,324 inhibits NMDA (NR1+NR2A) receptors expressed in Xenopus oocytes.
      A. Representative time course of NR1/NR2A currents, elicited by transient stimulations with 2
      µM glutamate + 10 µM glycine every 50 sec, while membrane potential was held at -80 mV, and significantly inhibited by 5 nM L-701,324 (#L-195).
      B. Superimposed current traces from the recording shown in A, following application of control and 5 nM L-701,324. Transient stimulation is indicated by an arrow.
    References - Scientific background
    1. Vyklicky, V. et al. (2014) Physiol. Res., 63, S191.
    2. Obrenovitch, T. P. et al. (1996) Br. J. Pharmacol., 117, 931.
    3. Obrenovitch, T.P. et al. (1997) Naunyn-Schmiedeberg's Arch Pharmacol., 355, 779.
    4. Liu, L. et al. (2021) Behav. Brain Res., 399, 113038.
    Scientific background

    Glutamate is a central excitatory neurotransmitter in the nervous system and his mediating signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception. N-methyl-D-aspartate (NMDA) receptor are the major subtype of glutamate receptors that participate in synaptic transmission. NMDA receptor consists of three different subunits termed GluN1-3. Activation of NMDA receptor carried out via interaction with glycine and glutamate1.
    L-701,324 (7-chloro-4-hydroxy-3(3-phenoxy) phenylquinoline-2-(H)-on) is an effective NMDA antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine binding site. It was found that L-701,324 when administered orally has an inhibitory effect on spreading depression (SD) initiations and propagation2. Moreover L-701,324 act as anticonvulsant and neuroprotective agent3. Recently it was shown that antidepressant effect of L-701,324 in mice IS mediated by elevating the hippocampal BDNF signaling cascade4.

    Target NMDA receptor
    Last update: 16/05/2021

    L-701,324 (#L-195) is a highly pure, synthetic and biologically active compound.

    For research purposes only, not for human use

    Applications

    Specifications

    Scientific Background

    Citations

    Citations
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