This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
- Zhang, W. et al. (2006) Biophys. J. 91, 1336.
- Alomone Labs L-Quisqualic acid activates GluA1 channels expressed in Xenopus oocytes.Time course of current reversible activation by 0.01, 0.1, 1 and 10 μM L-Quisqualic acid (#L-210), (holding potential -80 mV).
Glutamate is the main excitatory neurotransmitter in the CNS and is also involved in a variety of pathological conditions. AMPA-type glutamate receptors are tetrameric ion channels that mediate fast excitatory synaptic transmission in the mammalian brain.
L-Quisqualic acid (Quisqualate) is a selective agonist of AMPA receptors. Quisqualate binds to the AMPA receptor subunit GluR2 at the base of a deep cleft between two globular domains (GluR2-S1S2) causing the translation and rotation of domain S2 so that the cleft closes. The rate in which quisqualate dissociates from the AMPA receptor is primarily determined by the rate at which the receptor’s binding domain opens. Mutations that destabilize the closed-cleft conformation of the receptor increase the rate of quisqualate dissociation and alter its relative efficacy1. Interestingly, although glutamate is known to cause an increase in human melanoma cell viability quisqualate does not create a similar effect even though it stimulates PI hydrolysis, thus suggesting it is a “G-protein biased agonist”2.
L-Quisqualic acid (#L-210) is a highly pure, synthetic, and biologically active compound.
- Guinea pig Anti-GluR1 (GluA1) (extracellular) Antibody (#AGP-009)
- Anti-GluR1 (GluA1) (extracellular) Antibody (#AGC-004)
- Anti-GluR1 (GluA1) (extracellular)-ATTO-594 Antibody (#AGC-004-AR)
- Anti-GluR2 (GluA2) (extracellular) Antibody (#AGC-005)
- Anti-GluR2 (GluA2) (extracellular)-ATTO-488 Antibody (#AGC-005-AG)
- Anti-GluR3 (GluA3) (extracellular) Antibody (#AGC-010)
- Anti-GluR4 (GluA4) (extracellular) Antibody (#AGC-019)
- (S)-(-)-5-Fluorowillardiine (#F-205)
- CNQX (#C-140)
- DNQX disodium salt (#D-130)
- NBQX (#N-185)
- NBQX disodium salt (#N-186)
- GYKI 52466 hydrochloride (#G-125)
- CMPDA (#C-215)
- Cyclothiazide (#C-205)
- IDRA 21 (#I-140)
- AMPA Receptor Antagonist Explorer Kit (#EK-210)
- AMPA Receptor Modulator Explorer Kit (#EK-211)