L-Quisqualic acid

Quisqualate, (+)-Quisqualic acid
An Agonist of AMPA Receptors
Cat #: L-210
Alternative Name Quisqualate, (+)-Quisqualic acid
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 189.1
    Purity: 98%
    Effective concentration 0.01-100 µM.
    Structure
    • L-Quisqualic acid
    Chemical name (2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid.
    Molecular formula C5H7N3O5.
    CAS No.: 52809-07-1.
    PubChem CID 40539
    Activity L-Quisqualic acid is a selective AMPA receptor agonist1.
    References-Activity
    1. Zhang, W. et al. (2006) Biophys. J. 91, 1336.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 20 mM in H2O. Centrifuge all product preparations before use (10 000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • L-Quisqualic acid
      Alomone Labs L-Quisqualic acid activates GluA1 channels expressed in Xenopus oocytes.
      Time course of current reversible activation by 0.01, 0.1, 1 and 10 μM L-Quisqualic acid (#L-210), (holding potential -80 mV).
    References - Scientific background
    1. Zhang, W. et al. (2006) Biophys. J. 91, 1336.
    2. Gelb, T. et al. (2015) Biochem. Pharmacol. 98, 182.
    Scientific background

    Glutamate is the main excitatory neurotransmitter in the CNS and is also involved in a variety of pathological conditions. AMPA-type glutamate receptors are tetrameric ion channels that mediate fast excitatory synaptic transmission in the mammalian brain.

    L-Quisqualic acid (Quisqualate) is a selective agonist of AMPA receptors. Quisqualate binds to the AMPA receptor subunit GluR2 at the base of a deep cleft between two globular domains (GluR2-S1S2) causing the translation and rotation of domain S2 so that the cleft closes. The rate in which quisqualate dissociates from the AMPA receptor is primarily determined by the rate at which the receptor’s binding domain opens. Mutations that destabilize the closed-cleft conformation of the receptor increase the rate of quisqualate dissociation and alter its relative efficacy1. Interestingly, although glutamate is known to cause an increase in human melanoma cell viability quisqualate does not create a similar effect even though it stimulates PI hydrolysis, thus suggesting it is a “G-protein biased agonist”2.

    Target AMPA receptors
    Last update: 24/01/2020

    L-Quisqualic acid (#L-210) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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