Every lot is tried & tested in a relevant biological assay.
- Eguchi, J. et al. (2001) Pharmacol. Biochem. Behav. 68, 677.
- Alomone Labs MCI-225 blocks 5-HT3A receptors expressed in HEK 293T cells.5-HT3A receptor currents were elicited by 10 µM 5-HT, delivered every 3 minutes. MCI-225 (#M-190) was applied 30 seconds before stimulation at 10 and 100 nM, as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
MCI-225 is a psychoactive compound, a thienopyrimidine analogue that acts as a selective noradrenaline (NA) reuptake inhibitor with 5-HT3 channel blocking action. The compound demonstrates antidepressant-like activity with primary activity in the central nervous system.
Several studies have shown that MCI-225 exhibits improvement in amnesia in scopolamine treated rats and in basal forebrain lesion rats. Acute administration of MCI-225 inhibits the rise of threshold induced by footshock stress1.
It has been suggested that MCI-225 may affect attention, learning and memory2.
MCI-225 (#M-190) is a highly pure, synthetic, and biologically active compound.