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Zispin, Remergil, Remeron, 6-Azamianserin, Remergon
An Antagonist of 5-HT2, 5-HT3, Histamine H1 Receptors and α2-Adrenoceptor
Cat #: M-130
Alternative Name Zispin, Remergil, Remeron, 6-Azamianserin, Remergon
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 265.4
    Purity: >99.5%
    Effective concentration 10 nM – 1 µM.
    Chemical name 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine.
    Molecular formula C17H19N3.
    CAS No.: 61337-67-5
    PubChem CID 4205
    Activity Mirtazipine is an antidepressant agent; potent 5-HT2, 5-HT3 and histamine H1 receptor antagonist and moderately potent α2-adrenoceptor antagonist1.
    1. Kooyman, A.R. et al. (1994) Neuropharmacology. 33, 501.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 25-50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Mirtazapine blocks 5-HT3A receptors expressed in HEK 293T cells. 
      Alomone Labs Mirtazapine blocks 5-HT3A receptors expressed in HEK 293T cells. 
      5-HT3A receptor currents were elicited with 10 µM 5-HT, delivered every 3 minutes. Mirtazapine (#M-130) was applied 30 seconds before stimulation at 10 nM, 100 nM and 1 µM as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
    References - Scientific background
    1. Holland, J. et al. (2013) Psychiatr. Danub. 25, S286.
    2. Graves, S.M. et al. (2012) Pharmacol. Ther. 136, 343.
    3. Hartmann, P.M. (1999) Am. Fam. Physician. 59, 159.
    Scientific background

    Mirtazapine is a tetracyclic piperazinoazepine analogue of mianserin, an atypical antidepressant drug, approved by the FDA for the treatment of moderate to severe depression.

    Mirtazapine has minimal effect on monoamine reuptake and is classified as a NaSSA (noradrenergic and specific serotonergic antidepressant). The drug exhibits potent antagonism of central α2-adrenergic autoreceptors and heteroreceptors and antagonism of both 5-HT2 and 5-HT3 receptors and high affinity antagonism at histamine H1 receptor thus, leads to enhanced norepinephrine and serotonin release1,2.

    While the effectiveness of mirtazapine in treating depression appears to be more benefiting compared to the selective serotonin reuptake inhibitors (SSRI), it does exhibit several side effects including sedation and drowsiness, dry mouth, increased appetite, weight gain and dizziness. Mirtazapine is sometimes used as an alternative agent if the first antidepressant started is ineffective1,3.

    Target 5-HT3, 5-HT2, Histamine H1, α2 adrenergic receptors
    Last update: 24/12/2020

    Mirtazipine (#M-130) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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