This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
Xiang, Z. et al. (2011) ACS Chem. Neurosci. 2, 730.
Alomone Labs ML 218 inhibits T-type CaV channels heterologously expressed in Xenopus oocytes.A. Time course of CaV3.2 peak current amplitude, elicited by 100 ms voltage step from holding potential of -100 mV to -30 mV, delivered every 10 seconds. Application of 2 µM ML 218 (#M-165) inhibits the CaV3.2 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 2 µM ML 218 as indicated.
- Xiang, Z. et al. (2011) ACS Chem. Neurosci. 2, 730.
- Xie, X. et al. (2011) Probe Reports from the NIH Molecular Libraries Program.
T-Type Ca2+ channel inhibitors hold tremendous therapeutic potential for the treatment of pain, epilepsy, sleep disorders, essential tremor, and other neurological disorders1. ML 218 is a selective, potent inhibitor of T-type Ca2+ channels (IC50 values are 270 and 310 nM for CaV3.3 and CaV3.2 respectively in a patch EP assay). It has no effect on other members of the Ca2+ family of ion channels (L- and N-type Ca2+ channels) as well as multiple Na+ and K+ channels. ML 218 was found to be non-selective against hERG and many other ion channels. ML 218 possess excellent DMPK properties, acceptable in vivo rat PK, excellent brain levels and was efficacious in a haloperidol-induced catalepsy assay, a preclinical Parkinsonian model. ML 218 decreases burst activity in subthalamic nucleus (STN) neurons. Thus, ML 218 is a powerful new probe to study T-Type Ca2+ function both in vitro and in vivo2.
ML 218 (#M-165) is a highly pure, synthetic, and biologically active compound.
- Anti-CACNA1G (CaV3.1) Antibody (#ACC-021)
- Anti-CaV3.2 (CACNA1H) Antibody (#ACC-025)
- Anti-CaV3.3 (CACNA1I) Antibody (#ACC-009)
- Anti-CACNA1G (CaV3.1)-ATTO-594 Antibody (#ACC-021-AR)
- T-Type CaV Channel Blocker Explorer Kit (#EK-111)
- Mibefradil dihydrochloride hydrate (#M-150)
- Anti-KCNH2 (HERG) (extracellular) Antibody (#APC-109)
- hERG Related Channel Modulator Explorer Kit (#EK-109)
- ML 218 hydrochloride (#M-166)