A Selective Agonist of Neurotensin Receptor 1
Cat #: M-315
Alternative Name ML301
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 522.99
    Purity: >98%
    Effective concentration 1 nM – 1 µM.
    Chemical name (2S)-2-[[1-(7-chloroquinolin-4-yl)-2-(2,6-dimethoxyphenyl)imidazole-4-carbonyl]amino]-4-methylpentanoic acid.
    Molecular formula C27H27ClN4O5.
    Activity ML-301 is a selective agonist of NTR1 receptors, shown to stimulate NTR1-mediated calcium mobilization with EC50 of 289 nM1-2.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Soluble in DMSO.
    Centrifuge all products before handling (10000 x g 5 min).
    Storage of solutions Store at -20°C.
    It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.
      • Alomone Labs ML-301 activates human NTR1 receptors expressed in CHO-K1 cells.
        Dose-response curve of hNTSR1 activation by ML-301 (#M-315), normalized to maximum effect of neurotensin. Cells were loaded with Fluo-8 dye and stimulated with increasing concentrations of ML-301. Changes in intracellular Ca2+ following agonist application were detected as changes in maximum relative fluorescence using FLIPRTETRA™.
      • ML-301 is a fully selective imidazole-based agonist of neurotensin receptor 1 (NTR1). It stimulates NTR1-mediated calcium mobilization with an EC50 value of 289 nM1. The carboxylic acid moiety increases the compound’s solubility1.

        To date, four neurotensin receptors have been cloned from human: NTR1, NTR2, NTR3 and NTR4 which belong to the super family of G-protein coupled receptors (GPCRs). NTR1 mediates most of the known neurotensin ligand effects and is a potential therapeutic target2.

    Target Neurotensin Receptor 1
    Last update: 11/03/2019

    ML-301 (#M-315) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Related Products