Na+/H+ Exchanger (NHE) Antibody Explorer Kit (#AK-610) is a budget friendly screening package.
|Product Name||Cat #||Size|
|ANX-010||1 x 50 µl|
|ANX-002||1 x 50 µl|
|ANX-033||1 x 50 µl|
|ANX-005||1 x 50 µl|
|ANX-006||1 x 50 µl|
In order to function in optimal conditions, cells must maintain a close to neutral intracellular pH. They have adopted various mechanisms in order to do so, one of which is via Na+/H+ exchangers (NHEs). Genes belonging to this group are expressed along a very broad range of organisms and are essential for protecting cells against intracellular acidification1.
To date, nine genes have been identified in mammals; NHE1-9. These membrane proteins have 10-12 transmembrane domains depending on whether a splice variant is expressed and an intracellular N-terminal. The C-terminal domain can be either intracellular or extracellular, also depending whether a splice variant of the protein is involved. The C-terminal part of the protein also undergoes posttranslational modification such as phosphorylation2.
Under physiological conditions, the Na+/H+ exchanger mediates the exchange of one extracellular Na+ ion for one intracellular proton, thereby keeping the overall charge neutral1.