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Certificate of Analysis

  • Bioassay Tested

nAChR Agonist Explorer Kit

A Screening Package of nAChR Activators Economically Priced

Cat #: EK-204
Size: 7 Vials
Form: Lyophilized

1,1-Dimethyl-4-phenylpiperazinium iodide Cat #: D-125

Size: 1 g Source: Synthetic MW: 318.2 Purity: >98%
Effective concentration
0.5-200 µM.
Activity
DMPP activates α4 nicotinic channels expressed in Xenopus oocytes with IC50 0.77 μM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

(-)-Cytisine Cat #: C-130

Size: 10 mg Source: Synthetic MW: 190.2 Purity: >95%
Effective concentration
40 nM - 1 μM.
Activity
(-)-Cytisine is a potent and selective agonist of neuronal nAChR. It acts as a partial agonist at β2-containing nAChR1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer (up to 100mM stock). Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or six months at -20°C.

DMAB-anabaseine dihydrochloride Cat #: D-110

Size: 5 mg Source: Synthetic MW: 364.3 Purity: >98%
Effective concentration
0.1-10 µM.
Activity
DMAB-anabaseine dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChR) and antagonist of α4/β2 nAChR1. It blocks the acetylcholine induced α7 current with IC50 ~5 µM2. DMAB-anabaseine dihydrochloride can also displace isotopic (-)-cytisine and α-bungarotoxin binding to rat brain membranes with high affinity3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or six months at -20°C.

(-)-Nicotine ditartrate Cat #: N-175

Size: 1 g Source: Synthetic MW: 462.4 Purity: >99%
Effective concentration
0.5-200 µM.
Activity
(-)-Nicotine ditartrate activates α7 nAChR with EC50 ~25 µM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

PNU-120596 Cat #: P-350

Size: 10 mg Source: Synthetic MW: 311.72 Purity: >98% (HPLC)
Effective concentration
0.3-10 µM.
Activity
PNU-120596 is a potent and selective type-II positive allosteric modulator of α7 nicotinic acetylcholine receptors, shown to potentiate α7 currents in X. Laevis oocytes and in SH-EP1 cells with EC50 values of 1.6 µM and 216 nM, respectively1-2. Neuroprotective in vivo3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.
Reconstitution
Soluble to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

PNU 282987 Cat #: P-110

Size: 5 mg Source: Synthetic MW: 264.75 Purity: >98%
Effective concentration
EC50 ~ 5 μM.
Activity
PNU 282987 is a selective agonist of α7 nicotinic acetylcholine receptor (nAChR)1-2, with an EC50 of 5.6 μM in Xenopus oocytes3 and Ki of 26 nM in rat α7 nAChR1. Via modulating/enhancing hippocampal GABAergic neurotransmission, PNU 282987 improves auditory gating and enhances hippocampal oscillatory activity and therefore may offer a potential pharmacotherapy in the treatment of schizophrenia1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.

RJR 2403 oxalate Cat #: R-115

Size: 5 mg Source: Synthetic MW: 252.3 Purity: >99%
Effective concentration
1-100 µM.
Activity
RJR 2403 oxalate activates α4/β2 nAChR EC50 ~ 16 μM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Water. Centrifuge all product preparations before use (10000 x 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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