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Certificate of Analysis

  • Bioassay Tested

nAChR Antagonist Explorer Kit

A Screening Package of nAChR Blockers Economically Priced

Cat #: EK-205
Size: 16 Vials
Form: Lyophilized

Azemiopsin Cat #: STA-100

Size: 0.1 mg MW: 2544 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
0.5-10 µM.
Activity
Azemiopsin blocks the adult form (α1/β1/ε/δ) as well as the fetal form (α1/β1/γ/δ) nAChR1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Bungarotoxin Cat #: B-100

Size: 0.5 mg MW: 7984 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Natural peptide isolated from Bungarus multicinctus (Many-banded krait).
Effective concentration
1 nM - 3 μM.
Activity
α-Bungarotoxin blocks postsynaptic neuromuscular transmission via competitive inhibition of nicotinic ACh receptors (nAChRs), thereby preventing the depolarizing action on postsynaptic membranes and blocking neuromuscular transmission. Selective for α7 receptors (IC50 value of 1.6 nM) and α3/β4 receptors (IC50 value of >3 μM)1,2. The toxin also blocks GABA(A) receptor subtypes3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

αA-Conotoxin OIVA Cat #: STC-520

Size: 10 µg MW: 1848 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
100 - 250 nM.
Activity
αA-Conotoxin OIVA blocks α1/β1/g/d (fetal muscle) nAChR1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

αA-Conotoxin PIVA Cat #: STC-600

Size: 50 µg MW: 2651 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-20 nM
Activity
αA-Conotoxin PIVA reversibly blocks muscle α1/β1/γ/δ nicotinic ACh receptor1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

αC-Conotoxin PrXA Cat #: STC-620

Size: 50 µg MW: 3545 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-20 nM.
Activity
αC-Conotoxin PrXA reversibly blocks both adult and fetal mammalian muscle α1/β1/ε/δ and α1/β1/γ/δ nicotinic ACh receptor1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin AuIA Cat #: STC-960

Size: 0.25 mg MW: 1726 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
5 -20 µM.
Activity
α-Conotoxin AuIA is a blocker of α3/β4 nAChR subtypes1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin AuIB Cat #: STC-310

Size: 0.1 mg MW: 1572 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
0.1-5 μM
Activity
α-Conotoxin AuIB potently and specifically blocks mammalian neuronal nAChR channels α3/β41 and modulates high-voltage-activated (HVA) calcium channel through agonism of G-protein-coupled GABAB receptors 2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin EI Cat #: STC-900

Size: 0.1 mg MW: 2094 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
500 nM - 1 µM.
Activity
A selective blocker of α1/β1/γ/δ nAChR.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin GI Cat #: STC-500

Size: 50 µg MW: 1438 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10 nM - 1 μM.
Activity
α-Conotoxin GI inhibits α/δ site on mouse muscle-derived BC3H-1 nicotinic acetylcholine receptors (nAChR) expressed on postsynaptic membranes. Other site (α/γ site) on nicotinic receptors from Torpedo californica electric organ is also inhibited by α-Conotoxin GI1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin ImI Cat #: C-290

Size: 0.1 mg MW: 1351 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
0.1-10 μM
Activity
α-Conotoxin ImI potently and specifically blocks mammalian neuronal nAChR (α3/β2 > α7 > α3/β4)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin LtIA Cat #: STC-550

Size: 0.5 mg MW: 1601.8 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-10 µM.
Activity
α-Conotoxin LtIA reversibly blocks α3/β2 nicotinic ACh channel receptor1. Little or no block was obtained by 10 fold concentrations of the toxin on α4/β2 and α3/β4 nicotinic ACh receptors.1
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two week at 4°C or three months at -20°C.

α-Conotoxin MI Cat #: STC-370

Size: 0.1 mg MW: 1494 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
2-20 nM.
Activity
α-Conotoxin MI reversibly blocks fetal muscle α1/β1/γ/δ nicotinic ACh receptor1,2,3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin PeIA Cat #: STC-970

Size: 0.1 mg MW: 1652 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
20-50 nM.
Activity
α-Conotoxin PeIA blocks α9/α10 and α3/β2 nAChR1. Also inhibits N-type Ca2+ channels2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two week at 4°C or three months at -20°C.

α-Conotoxin PIA Cat #: STC-870

Size: 50 µg MW: 1981 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
0.20-1 µM
Activity
α-Conotoxin PIA is a selective antagonist of α6-containing nAChR1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 g x 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

Huwentoxin-I Cat #: STH-050

Size: 50 µg MW: 3750 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
50-200 nM.
Activity
An inhibitor of TTX-sensitive voltage-gated Na+ channels and N-type voltage-gated Ca2+ channels1. Also found to block neuromuscular transmission2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

(-)-Lobeline hydrochloride Cat #: L-120

Size: 100 mg Source: Synthetic MW: 373.9 Purity: >98%
Effective concentration
0.1-100 µM.
Activity
(-)-Lobeline hydrochloride is a high affinity modulator of nicotinic acetylcholine receptors. It inhibits α7 nAChRs with IC50 of 8.5 µM1.
It also acts on the α4/β2 combination2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Ethanol/water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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