NaV1.8 Channel Basic Research Pack

All You Need for NaV1.8 Channel Research
  • Lyophilized Powder
  • Antigen Incl.
Cat #: ESB-003
Sizes: 5 Vials
Last update: 23/04/2019

Alomone Labs is pleased to offer the NaV1.8 Channel Basic Research Pack (#ESB-003). The Research Pack contains all you need for NaV1.8 research: Antibodies recognizing different domains of the channel and a NaV1.8 specific blocker, all in one economical package!

For research purposes only, not for human use
Compounds
Product Name Cat # Size
Anti-NaV1.8 (SCN10A) Antibody
ASC-016 1 x 0.2 ml
Anti-NaV1.8 (SCN10A) (extracellular) Antibody
ASC-028 1 x 0.2 ml
A-803467
A-105 1 x 50 mg
Scientific Background
Scientific Background

Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-1.9. 2-3 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels.4-5 Expression of the α subunit isoform is developmentally and tissue specific.

Two TTX-resistant NaV channels are expressed in dorsal root ganglion (DRG) neurons, NaV1.8 and NaV1.9. The NaV1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons.4-6 TTX-resistant channels have been suggested to play an important role in nociceptive transmission.

Recently, involvement of NaV1.8 in multiple sclerosis (MS) was suggested due to up-regulation of both, mRNA and protein, in Purkinje cells of MS patients and also in animal models.6

References
  1. Lai, J. et al. (2003) Curr. Opin. Neurobiol. 13, 291.
  2. Renganathan, Met al. (2003) Brain Res959, 235.
  3. Fang, X. et al. (2002) J. Neurosci22, 7425.
  4. Wu, Let al. (2002) Neuro. Report 13, 2547.
  5. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27.
  6. Fjell, Jet al. (2000) Neuro. Report 11, 199.
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