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(-)-Nicotine ditartrate

An Agonist of nAChR

Cat #: N-175
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 462.4
    Purity: >99%
    Form Lyophilized powder.
    Effective concentration 0.5-200 µM.
    Structure
    Chemical name (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt.
    Molecular formula C18H26N2O12.
    CAS No.: 65-31-6
    Activity (-)-Nicotine ditartrate activates α7 nAChR with EC50 ~25 µM1.
    References-Activity
    1. Amar, M. et al. (1993) FEBS Lett. 327, 284.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Water. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs (-)-Nicotine ditartrate activates α3/β4 nAChR heterologously expressed in Xenopus oocytes.
      Alomone Labs (-)-Nicotine ditartrate activates α3/β4 nAChR heterologously expressed in Xenopus oocytes.
      A. Time course of current repetitive and reversible activation by 100 µM (-)-Nicotine ditartrate (#N-175), applied by perfusion every 100 seconds, in the presence of 3 µM PNU 282987 (#P-110). Holding potential was -80 mV.
    References - Scientific background
    1. Xiao, Y. et al. (1998) Mol. Pharmacol. 54, 322.
    2. Rand M.J. et al. (1989) Prog. Brain Res. 79, 3.
    3. Athawale R.B. et al. (2010) Asian J. Chem. 22, 2501.
    Scientific background

    The nAChR complex, a cholinergic receptor, is composed of five subunits and is found in both the peripheral and central nervous systems. In the mammalian brain, there are as many as nine α subunits (α2 to α10) and three β subunits (β2 to β4). The most abundant receptor subtypes in the brains of humans are α4/β2, α3/β4, and α71.

    (-)-Nicotine ditartrate is a potent agonist of AChR. It stimulates autonomic ganglia and skeletal muscle neuromuscular junctions2. (-)-Nicotine ditartrate is a salt of nicotine of pharmaceutical grade and tartaric acid used for preparation of the products for smoking cessation and as an analytical standard3.

    Target nAChR
    Lyophilized Powder
    Last update: 06/11/2022

    (-)-Nicotine ditartrate (#N-175) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use

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