This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
- Alomone Labs Nitrendipine inhibits L-type voltage-gated Ca2+ currents expressed in Xenopus oocytes.A. Time course of CaV1.2/α2-δ1/β2a (L-type) current inhibition by 200 µM of Nitrendipine (#N-155). Currents were elicited by application of voltage steps from a holding potential of -100 mV to 0 mV (100 msec). B. Superimposed example traces of current responses before and during perfusion of 200 µM Nitrendipine as indicated.
- Furukawa, T. et al. (2005) J. Cardiovasc. Pharmacol. 45, 241.
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- Hering, S. et al. (1998) Trends Pharmacol. Sci. 19, 439.
- Hockerman, G.H. et al. (1997) Ann. Rev. Pharmacol. Toxicol. 37, 361.
- Haller, H. (2008) Int. J. Clin. Practice 62, 781.
- Peterson, B.Z. et al. (1996) J. Biol. Chem. 271, 5293.
- Furukawa, T. et al. (2005) .J. Cardiovasc. Pharmacol. 45, 241.
Native voltage-gated Ca2+ channels (VGCC, CaV) are pharmacologically classified into at least five different subclasses (L-, N-, P-, Q-, and R-type), the characteristics of which are determined by the pore- forming α1 subunit. The subunits CaV1.1-1.4 (α1S, α1C, α1D and α1F) form L-type Ca2+ channels and bind dihydropyridines (DHPs) with high affinity1,2.
L-type (CaV1), voltage-gated Ca2+ channels are plasma membrane protein complexes which allow the passage of Ca2+ ions into cells following depolarization of the membrane potential.
They are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases3,4.
Nitrendipine is a dihydropyridine Ca2+ channel blocker. Once Nitrendipine is metabolized, it reaches the cells of the smooth muscles and cardiac muscle. It binds more effectively with L-type calcium channels in smooth muscle cells as a result of its lower resting membrane potential5.
10 μM of Nitrendipine inhibited 50% of L-type current expressed in Xenopus oocytes, with no effect on T-type channels6.
Nitrendipine (#N-155) is a highly pure, synthetic, and biologically active compound.