NMDA Receptor Interacting Protein Antibody Explorer Kit

A Screening Package of NMDA Receptor Interacting Protein Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-615
Sizes: 22 Vials
Last update: 03/09/2018

NMDA Receptor Interacting Protein Antibody Explorer Kit (#AK-615) contains specific antibodies directed against key proteins known to interact with NMDA Receptors.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-AKAP150 Antibody
APZ-031 1 x 50 µl
Anti-Homer1 Antibody
APZ-026 1 x 50 µl
Anti-Kidins220 Antibody
APZ-017 1 x 50 µl
Anti-Pannexin 1 Antibody
ACC-234 1 x 50 µl
Anti-PICK1 Antibody
APZ-014 1 x 50 µl
Anti-PSD-93 Antibody
APZ-002 1 x 50 µl
Anti-PSD-95 Antibody
APZ-009 1 x 50 µl
Anti-SAP-97 Antibody
APZ-010 1 x 50 µl
Anti-Shank1 Antibody
APZ-011 1 x 50 µl
Anti-Shank3 Antibody
APZ-013 1 x 50 µl
Anti-Sigma-1 Receptor Antibody
AIP-006 1 x 50 µl
Scientific Background
Scientific Background

NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functional NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit.

Ca2+ entry through the NMDAR regulates numerous downstream signaling pathways including long term potentiation (a molecular model of memory) and synaptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinson’s and Alzheimer’s disease.

NMDA receptors expression and function are modulated by a variety of factors including receptor trafficking to the synapses and internalization as well as phosphorylation and interaction with other intracellular proteins.

References
  1. Dingledine, R. et al. (1999) Pharmacol. Rev51, 7.
  2. Mayer, M.L. and Armstrong, N. (2004) Annu. Rev. Physiol66, 161.
  3. Prybylowski, K. and Wenthold, R.J. (2004) J. Biol. Chem279, 9673.
  4. Mayer, M.L. (2006) Nature 440, 456.
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