This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
Huang, L. et al. (2004) J. Pharmacol. Exp. Ther. 309, 193.
Alomone Labs NNC 55-0396 dihydrochloride inhibits CaV3.2 channels heterologously expressed in Xenopus oocytes.A. Time course of CaV3.2 peak current amplitude, elicited by 100 ms voltage step from holding potential of -100 mV to -20 mV, delivered every 10 seconds. Application of 10 µM NNC 55-0396 dihydrochloride (#N-205) inhibits the CaV3.2 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 10 µM NNC 55-0396 dihydrochloride, as indicated.
NNC 55-0396 dihydrochloride, is a structural analog of mibefradil (Ro 40-5967) that inhibits both T-type and high-voltage-activated (HVA) Ca2+ channels with a higher selectivity for T-type Ca2+ channels. NNC 55-0396 exerts no effect against high voltage Ca2+ channels at 100 μM, but inhibits T-type channels in HEK293 cells with a potency comparable to that of mibefradil (IC50 values of 6.8 versus 10.1 μM)1. NNC 55- 0396 can be an essential tool in preventing human ovarian cancer cell proliferation as a result of its ability to inhibit the function of T-type Ca2+ channels. It is believed that NNC 55-0396 may function by dissolving in or passing through the plasma membrane of cells2.
NNC 55-0396 dihydrochloride (#N-205) is a highly pure, synthetic, and biologically active compound.
- Anti-CACNA1G (CaV3.1) Antibody (#ACC-021)
- Anti-CaV3.2 (CACNA1H) Antibody (#ACC-025)
- Anti-CaV3.3 (CACNA1I) Antibody (#ACC-009)
- Anti-CACNA1G (CaV3.1)-ATTO-594 Antibody (#ACC-021-AR)
- T-Type CaV Channel Blocker Explorer Kit (#EK-111)
- Mibefradil dihydrochloride hydrate (#M-150)
- TTA-A2 (#T-140)
- Non-L-Type CaV Channel Antibody Explorer Kit (#AK-216)