P2X7 Receptor Deluxe Research Pack

All You Need for P2X7 Receptor Research
    Cat #: ESD-710
    Last update: 24/01/2020

    P2X7 Receptor Deluxe Research Pack (#ESD-710) contains all you need for P2X7 receptor research: P2X7 receptor -specific antibodies and pharmacological tools, all in one budget friendly package!

    For research purposes only, not for human use

    Compounds

    Compounds
    Product NameCat #Size
    Antibodies
    Anti-P2X7 Receptor Antibody
    APR-004 1 x 0.2 ml
    Anti-P2X7 Receptor-ATTO-550 Antibody
    APR-004-AO 1 x 50 µl
    Anti-P2X7 Receptor (extracellular) Antibody
    APR-008 1 x 0.2 ml
    Anti-P2X7 Receptor (extracellular)-FITC Antibody
    APR-008-F 1 x 50 µl
    Activators/Agonists
    BzATP triethylammonium salt
    A-385 1 x 10 mg
    Blockers/Antagonists
    A-740003
    A-420 1 x 50 mg
    A-804598
    A-415 1 x 25 mg
    JNJ-47965567
    J-115 1 x 25 mg
    KN-62
    K-120 1 x 10 mg
    ZINC9315614
    Z-145 1 x 25 mg
    Modulators
    Garcinolic acid
    G-155 1 x 1 mg
    GW 791343 hydrochloride
    G-115 1 x 25 mg

    Scientific Background

    Scientific Background
      • The P2X7 purinergic receptor is a member of the ionotropic P2X receptor family that is activated by ATP. To date, this family consists of seven receptor subtypes, named P2X1-P2X7, all of which have been cloned.

        The various P2X receptors show distinct expression patterns. P2X1-6 receptors have been found in the central and peripheral nervous system, while the P2X7 receptor is found in cells of the immune system, particularly in antigen-presenting cells and microglia.

        The P2X7 receptor mediates the release of proinflamatory cytokines and stimulation of transcription factors and may also play an important role in apoptosis1-3.

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